1 Product identity
Ingredient risk
Contains restricted ingredients
Pack #1, Joint Health Pack
BrandDouglas Laboratories→Other Combinations Other (e.g. tea bag) 65 ingredients 1 banned 1 high-risk 7 caution DSLD #31417Net contents: 60 Pack(s)
Target: Adults and Children 4 years and above
DSLD entry: 2014-03-25
2 Ingredients (65)
IngredientGroupSafety
Rehab Support Proprietary BlendProprietary Blend (Combination)—
L-Aspartic AcidAspartic Acid—
TrypsinTrypsin—
ChymotrypsinChymotrypsin—
CapsicumCapsicum—
German ChamomileGerman Chamomile —
MucopolysaccharidesMucopolysaccharide—
Rutin N.F.Rutin—
Pancreatin 8XBlend (non-nutrient/non-botanical)—
N-Acetyl-L-Cysteine/L-Cysteine HClBlend (Combination)—
ProanthocyanidinsProanthocyanidins (unspecified)—
Standardized Curcumin ExtractCurcumin—
Resveravine(R)Grape —
5 mg of viniferinViniferin—
Citrus Bioflavonoid ComplexFlavonoid (mixture)—
PABAPABA—
Trace ElementsBlend (Combination)—
CelluloseCellulose—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ High-risk ingredient — documented serious harm
Inositol — GDM prevention — 4 g/day from first trimester in high-risk women [2]
⛔ Contains an ingredient banned in ≥1 country
Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Iron — Iron supplementation in iron-replete patients may increase cardiovascular and cancer risk — always document deficiency before prescribing [1].
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
3 Safety cross-reference
Vitamin A — Conditionally Safe
⚠ Teratogenic at high doses
⚠ Hepatotoxic with chronic excess
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Thiamin — Use with Caution
⚠ Very low toxicity
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Limited Evidence
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Biotin — Generally Safe
⚠ Interferes with troponin and thyroid lab assays
Pantothenic Acid — Limited Evidence
⚠ Diarrhea at very high doses
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Iron — Use with Caution
⚠ GI upset, constipation
⚠ Fatal toxicity in children
Phosphorus — Generally Safe
⚠ Excess impairs calcium absorption
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Selenium — Conditionally Safe
⚠ Selenosis >400 mcg
⚠ Diabetes risk at high doses
Copper — Conditionally Safe
⚠ Hepatotoxicity at high doses
Manganese — Conditionally Safe
⚠ Neurotoxicity with chronic excess
Chromium — Conditionally Safe
⚠ Hypoglycemia with diabetes meds
⚠ Rare renal/hepatic toxicity
Molybdenum — Generally Safe
⚠ Very low toxicity
Potassium — Conditionally Safe
⚠ Hyperkalemia risk
⚠ Dangerous with ACE inhibitors
Glucosamine — Limited Evidence
⚠ Shellfish allergy
⚠ May affect glucose
Chondroitin — Limited Evidence
⚠ May enhance anticoagulants
Methylsulfonylmethane — Generally Safe
⚠ GI effects
⚠ Headache
Betaine HCl — Limited Evidence
⚠ Heartburn, GI burning if used without protein meals
⚠ Not for those on H. pylori treatment
L-Phenylalanine — Limited Evidence
⚠ Dangerous in PKU
⚠ May raise blood pressure
L-Methionine — Limited Evidence
⚠ Raises homocysteine levels
⚠ May promote tumor growth
Bromelain — Conditionally Safe
⚠ Increased bleeding risk
⚠ GI upset
Chloride — Limited Evidence
⚠ Co-ingested with sodium
Boswellia — Generally Safe
⚠ GI discomfort
⚠ May enhance anticoagulants
Green Tea Extract — Limited Evidence
⚠ HEPATOTOXICITY >800 mg EGCG
⚠ Iron absorption inhibition
Quercetin — Conditionally Safe
⚠ Inhibits CYP3A4
⚠ Affects cyclosporine levels
Resveratrol — Conditionally Safe
⚠ Estrogenic activity
⚠ CYP enzyme inhibition
Hyaluronic acid — Generally Safe
⚠ Generally well tolerated
⚠ Theoretical concern in active cancer (promotes angiogenesis)
Inositol — High risk
⚠ GI disturbance at high doses (>12 g)
⚠ May lower blood glucose
Choline — Generally Safe
⚠ Fishy odor at high doses
Astaxanthin — Generally Safe
⚠ May lower blood pressure
Boron — Conditionally Safe
⚠ Reproductive toxicity in animals
Vanadium — Limited Evidence
⚠ GI toxicity: nausea, vomiting, diarrhea
⚠ Green tongue
Sodium — Limited Evidence
⚠ Hypertension
⚠ Fluid retention
Silicon — Generally Safe
⚠ Very low toxicity
Titanium Dioxide — Banned in ≥1 country
⚠ EFSA: can no longer be considered safe as food additive (2021)
⚠ Genotoxicity concern (nanoparticles)
4 Label claims
• All Other
5 Data source
DSLD ID31417
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2014-03-25
6 More from Douglas Laboratories
View Douglas Laboratories Safety Scorecard → 788 products
A-Potene 10A-Potene 25A-Retic Natural Herbal FormulaA-Retic Natural Herbal FormulaA.R. FormulaA.R.M.D. Eye Support7 Cite this page
Vancouver
Pkhakadze G. Pack #1, Joint Health Pack — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jun 24]. Available from: https://supplement.ge/products/pack-1-joint-health-pack-31417/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG