✓ No active regulatory warningsFDA MedWatch, EMA EudraVigilance, WHO VigiBase, WADA Prohibited List · 2026-05-29
📰Read the full Resveratrol evidence review on GMJ News →Complete clinical article, references and updates on news.gmj.ge. This page is the structured safety summary.⚠ Patient expecting anti-aging miracle — no human longevity data; bioavailability <1% [2]
⚠ Patient on anticoagulants — antiplatelet activity [1]
⚠ Patient citing 'French Paradox' as reason to drink wine for resveratrol — the math doesn't work (1.5 mg/glass vs 150–500 mg supplement) [1]
⚠ Estrogenic activity — caution in hormone-sensitive conditions [1]
ℹ️ Not obtained from food. A plant polyphenol (grapes, berries) present in tiny amounts; there is no daily dietary target.
🔬 Lab interpreter
Recommended test
No routine monitoring
No routine monitoring
Reference range / target
N/A
N/A
No validated biomarker for resveratrol response [2].
Full lab monitoring ↓⚕ For professionals — confirm ranges against your local laboratory.
Clinical verdict
Resveratrol is the most over-hyped supplement relative to its clinical evidence. SIRT1 activation is real in vitro, but <1% oral bioavailability makes clinical translation nearly impossible. Red wine provides only 1.5 mg/glass (negligible). 15,000+ publications, essentially zero proven clinical benefits. Pterostilbene (4× bioavailability) may be the better bet. The 'French Paradox' is not resveratrol [1] [2].
1 How much do I need?
👤 Adults: Specific dosage data under clinical review
👴 Elderly: Specific dosage data under clinical review
🤰 Pregnancy: See guidance
Estrogenic activity. No safety data. Avoid [1].
👦 Pediatric: See guidance
No data. Not recommended for children [1].
🏃 Athletes: Standard dose
⚖️ Obesity: Standard dose
Fat-soluble compounds may require dose adjustment in obesity.
🩺 Renal: Consult specialist
Dose adjustment may be needed in renal impairment.
🌱 Vegan: Standard dose
How to take
🍽 Timing: With food (fat enhances absorption modestly) [2].
💊 With food: Take with fat-containing meal [2].
2 Which form?
| Form | Bioavailability | Vegan | Cost |
|---|---|---|---|
| ['Trans-resveratrol', 'preferred', 'The bioactive isomer. Most supplements contain this form. From Polygonum cuspidatum (Japanese knotweed) or synthetic [1].'] | Standard | Check label | |
| ['Cis-resveratrol', '', 'Less studied isomer. Some conversion occurs in the body [1].'] | Standard | Check label | |
| ['Micronized/nano-resveratrol', '', 'Formulations to improve the dismal bioavailability. Emerging but not yet standard [2].'] | Standard | Check label | |
| ['Pterostilbene', '', "Dimethylated analog of resveratrol with ~4× better bioavailability. Similar SIRT1 activation. Gaining popularity as a 'next-gen resveratrol' [2]."] | Standard | Check label |
3 Common questions
Can I get resveratrol from red wine? ▼
Not therapeutically. One glass of red wine contains ~1.5 mg resveratrol; supplements provide 150–500 mg. You would need 100+ glasses daily — the alcohol would kill you long before the resveratrol helped [1]. The 'French Paradox' is likely explained by overall dietary pattern and lifestyle, not resveratrol.
Is resveratrol the anti-aging miracle? ▼
In a word: no, at least not yet in humans. SIRT1 activation is well-established in vitro, and resveratrol extends lifespan in yeast, worms, and some (but not all) mouse studies [1]. Human longevity trials do not exist. The bioavailability problem (<1%) makes it unclear whether oral resveratrol reaches tissues at effective concentrations [2].
Is pterostilbene better? ▼
Pterostilbene has approximately 4× better bioavailability than resveratrol due to its dimethylated structure, and has similar SIRT1/AMPK activity [2]. It is emerging as a potentially superior alternative but has much less clinical trial data.
Does resveratrol interfere with exercise benefits? ▼
A controversial 2014 study suggested high-dose resveratrol blunted the cardiovascular benefits of exercise in elderly men. This has NOT been consistently replicated, but it raised caution about concurrent supplementation with exercise [2].
4 Clinical evidence
Strong
SIRT1 activation in vitro: well-established. Resveratrol mimics caloric restriction signaling in cellular models [1]. Extremely poor bioavailability (<1%): well-established pharmacokinetic limitation [2]. HIGH
Moderate
Glucose metabolism: meta-analysis of 11 RCTs showed modest fasting glucose reduction in diabetics (−0.3 mmol/L) but NOT in non-diabetics [2]. Inflammatory markers: some trials show CRP reduction [2]. Cognitive function: RESHAW trial (n=80) showed improved cerebrovascular function with 150 mg/day in postmenopausal women [2]. MODERATE
Insufficient
Cardiovascular events: no outcome trials despite the 'French Paradox' hypothesis [1]. Cancer prevention/treatment: thousands of preclinical studies but essentially zero positive clinical trials [1]. Longevity in humans: unproven (studies in model organisms are mixed) [2]. Skin aging: topical data limited [1]. LOW
5 Safety, toxicity & adverse events
Relative
⚠ Concurrent anticoagulants — antiplatelet effect
⚠ Hormone-sensitive cancers — weak estrogenic activity (mixed evidence)
⚠ Concurrent CYP3A4 substrates — resveratrol inhibits CYP3A4 and CYP1A2
⚠ Concurrent immunosuppressants — may modulate immune response
🚩 Red flags
● Patient on anticoagulants + resveratrol — antiplatelet effects [1]
● Patient with hormone-sensitive cancer + resveratrol — estrogenic activity [1]
6 Interactions
Drug interactions
Anticoagulants/antiplatelets Moderate
Mechanism: Resveratrol inhibits platelet aggregation and may inhibit CYP enzymes involved in warfarin metabolism. [1]
Effect: Additive bleeding risk. [1]
Action: Monitor for bleeding. Consider avoiding at doses >250 mg/day with anticoagulants [1].
CYP3A4 substrates Moderate
Mechanism: Resveratrol inhibits CYP3A4 and CYP1A2 at high concentrations in vitro. [2]
Effect: Potentially elevated drug levels. Clinical significance uncertain at standard doses. [2]
Action: Monitor if on narrow therapeutic index drugs [2].
Supplement synergies
Quercetin · 500 mg quercetin
Complementary polyphenols with overlapping anti-inflammatory/senolytic mechanisms [1].
Complementary polyphenols with overlapping anti-inflammatory/senolytic mechanisms [1].
NMN or NR (nicotinamide precursors) · 250–500 mg NMN
Resveratrol activates SIRT1 which requires NAD+. NMN/NR raise NAD+ levels. Theoretically synergistic [1].
Resveratrol activates SIRT1 which requires NAD+. NMN/NR raise NAD+ levels. Theoretically synergistic [1].
7 Regulatory
United States (FDA): Dietary supplement. No health claims. GRAS for food use [1].
European Union (EFSA): Available as supplement. No authorized health claims [1].
Japan: Available as supplement. Popular in anti-aging market.
South Korea: Available as dietary supplement.
8 US supplement products
296
on-market products containing Resveratrol (NIH DSLD)
Brands carrying Resveratrol (151)
Click a brand to see its Resveratrol products.
9 Frequently paired with
10 Cite this page
Vancouver: Pkhakadze G. Resveratrol — safety profile [Internet]. Tbilisi: PHIG; 2026 [cited 2026 Jul 17]. Available from: https://supplement.ge/ingredients/resveratrol/
APA 7th: Pkhakadze, G. (2026). Resveratrol — Safety profile. Public Health Institute of Georgia. https://supplement.ge/ingredients/resveratrol/
📋 Editorial information
Author: Prof. G. Pkhakadze, MD, MPH, PhD
Institution: Public Health Institute of Georgia (PHIG)
Affiliation: David Tvildiani Medical University (DTMU)
First published: January 2026
Last reviewed: 2026-05-29
Next review: January 2027
References: 4 cited sources
COI: SupplementIndex receives no funding from supplement manufacturers. All content independently authored by PHIG.
Process: Systematic literature review
📄 License & reuse
Published under Creative Commons Attribution 4.0 International (CC BY 4.0). You may share and adapt for any purpose with attribution.
Pkhakadze G. "Resveratrol — Safety Profile." SupplementIndex, PHIG, 2026. https://supplement.ge/ingredients/resveratrol/ CC BY 4.0.
GP
Prof. G. Pkhakadze, MD, MPH, PhD
Professor of Public Health · Head of Department, DTMU
Editor-in-Chief, Georgian Medical Journal (ISSN 3088-4322)
Chair, Public Health Institute of Georgia · UEMS Public Health Section
Educational and public health purposes. CC BY 4.0. Consult your healthcare provider before starting any supplement. Corrections: info@accreditation.ge. Publisher: PHIG