⚠️
Major drug interaction. This ingredient has clinically significant drug interactions. See Drug Interactions below before use.
SAFE

Iron

Ferrous sulfate
Likely Safe V1 Verified Minerals
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PubMed Studies
5,975
PubChem CID
📊 Effectiveness
Iron deficiency anaemia
Evidence Grade A · 68 studies · n=28,000 · Meta-analysis available
Effective
Fatigue
Evidence Grade A · 22 studies · n=3,800 · Meta-analysis available
Likely Effective
Cognitive function
Evidence Grade B · 15 studies · n=2,200
Possibly Effective

Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
Kidney diseasePossibly safeMedical supervision required — IV iron often preferred
GeneralPossibly safe45mg/day
PregnancyLikely safe27mg/day (EU RDA pregnant women)
ChildrenPossibly safe7-15mg/day (age-dependent)
ElderlyPossibly unsafeAvoid iron supplementation without confirmed deficiency
🚫 Contraindications & Warnings

Consult a healthcare professional before use if you have kidney disease, are pregnant, or take prescription medications. Mineral supplements can interact with certain medications.

💊 Drug Interactions (8)
🔴 Levothyroxine
Major
Thyroid medications
Management: Separate by minimum 4 hours. Critical and under-recognized interaction.
🔴 Methyldopa
Major
Antihypertensives
Management: Separate by 2 hours. Critical interaction.
🔴 Ciprofloxacin / Doxycycline
Major
Antibiotics
Management: Separate by 2-3 hours.
🟡 Captopril / Enalapril
Moderate
ACE inhibitors
Management: Separate by 2 hours.
🟡 Mycophenolate
Moderate
Immunosuppressants
Management: Separate by 2 hours. Monitor drug levels.
🟡 Quinolone antibiotics
Moderate
Antibiotic
Management: Separate by at least 2 hours.
⚪ Metformin
Minor
Antidiabetics
Management: Monitor iron status.
⚪ Calcium supplements
Minor
Mineral supplement
Management: Take at different meals or 2 hours apart.
⚠️ Adverse Effects (2)
Liver damage
rare (overdose or haemochromatosis) Life threatening
Hepatic system
Iron accumulation causes oxidative hepatic damage. Serious in haemochromatosis or overdose.
Constipation and GI upset
very common (>1:10) Mild
Gastrointestinal system
Nausea, constipation, dark stools, GI irritation. Take with food to reduce. Ferrous bisglycinate better tolerated.
🏷️ Other Names
Ferrous bisglycinate Ferrous sulfate Ferric iron Iron bisglycinate Ferrochel Ferric pyrophosphate Iron (as ferrous)
Updated: 2026-04-11
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