✓ No active regulatory warningsFDA MedWatch, EMA EudraVigilance, WHO VigiBase, WADA Prohibited List · 2026-05-29
📰Read the full Chloride evidence review on GMJ News →Complete clinical article, references and updates on news.gmj.ge. This page is the structured safety summary.⚠ Comes with dietary salt — no independent supplement needed [1]
⚠ Hypochloremic metabolic alkalosis: from vomiting/NG suction [1]
ℹ️ Not obtained from food. Not applicable — this is not obtained from food in meaningful amounts; supplementation is the practical route.
🔬 Lab interpreter
⚕ For professionals — confirm ranges against your local laboratory.
Clinical verdict
Chloride is the anion half of table salt (NaCl). Comes with dietary sodium. Deficiency only from vomiting/NG suction/diuretics. NOT supplemented independently [1].
1 How much do I need?
👤 Adults: Specific dosage data under clinical review
👴 Elderly: Specific dosage data under clinical review
🤰 Pregnancy: See guidance
Dietary [1].
👦 Pediatric: See guidance
Comes with salt [1].
🏃 Athletes: Standard dose
⚖️ Obesity: Standard dose
Fat-soluble compounds may require dose adjustment in obesity.
🩺 Renal: Consult specialist
Dose adjustment may be needed in renal impairment.
🌱 Vegan: Standard dose
How to take
🍽 Timing: N/A [1].
💊 With food: N/A [1].
🚫 Avoid: N/A [1].
2 Which form?
| Form | Bioavailability | Vegan | Cost |
|---|---|---|---|
| ['Table salt (NaCl)', '', 'Provides chloride with sodium [1].'] | Standard | Check label |
3 Common questions
Do I need chloride supplements? ▼
No — chloride comes with dietary salt. Deficiency occurs only with prolonged vomiting or NG suction [1].
4 Clinical evidence
Strong
Essential for HCl production and acid-base: basic physiology [1]. HIGH
Moderate
Metabolic alkalosis from chloride depletion (vomiting, NG suction) — treated with NaCl [1]. MODERATE
Insufficient
Independent chloride supplementation for any condition [1]. LOW
5 Safety, toxicity & adverse events
Relative
⚠ Significant kidney disease — electrolyte handling
⚠ Metabolic acidosis/alkalosis states — chloride load matters
⚠ Usually obtained adequately with dietary sodium/potassium salts
🚩 Red flags
● Hypochloremia from vomiting — replace with NaCl [1]
6 Interactions
7 Regulatory
IOM: AI: 2.3 g/day [1].
8 US supplement products
477
on-market products containing Chloride (NIH DSLD)
Brands carrying Chloride (140)
Click a brand to see its Chloride products.
9 Frequently paired with
10 Cite this page
Vancouver: Pkhakadze G. Chloride — safety profile [Internet]. Tbilisi: PHIG; 2026 [cited 2026 Aug 15]. Available from: https://supplement.ge/ingredients/chloride/
APA 7th: Pkhakadze, G. (2026). Chloride — Safety profile. Public Health Institute of Georgia. https://supplement.ge/ingredients/chloride/
📋 Editorial information
Author: Prof. G. Pkhakadze, MD, MPH, PhD
Institution: Public Health Institute of Georgia (PHIG)
Affiliation: David Tvildiani Medical University (DTMU)
First published: January 2026
Last reviewed: 2026-05-29
Next review: February 2027
References: 1 cited sources
COI: SupplementIndex receives no funding from supplement manufacturers. All content independently authored by PHIG.
Process: Systematic literature review
📄 License & reuse
Published under Creative Commons Attribution 4.0 International (CC BY 4.0). You may share and adapt for any purpose with attribution.
Pkhakadze G. "Chloride — Safety Profile." SupplementIndex, PHIG, 2026. https://supplement.ge/ingredients/chloride/ CC BY 4.0.
GP
Prof. G. Pkhakadze, MD, MPH, PhD
Professor of Public Health · Head of Department, DTMU
Editor-in-Chief, Georgian Medical Journal (ISSN 3088-4322)
Chair, Public Health Institute of Georgia · UEMS Public Health Section
Educational and public health purposes. CC BY 4.0. Consult your healthcare provider before starting any supplement. Corrections: info@accreditation.ge. Publisher: PHIG