⛔ Red — banned or high-risk ingredients
Auto-flagged from PHIG regulatory data. Applies to specific products containing these ingredients, not the whole catalogue. Flags show countries named in the source data.
GDM prevention — 4 g/day from first trimester in high-risk women [2]
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France banned TiO₂ in food from January 2020, first EU country.
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Hepatotoxicity cases including liver failure — limit 6 months [1]
Dog owner not warned about xylitol toxicity — potentially fatal to dogs [1]
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Not approved for OTC sale as supplement.
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dards. Drug interaction warnings required [2]. || France :: Banned from sale as a supplement (2000) due to drug interaction concerns [3]. ||
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Banned April 2023 following DTU risk assessment. All products withdrawn.
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ates (FDA) :: Dietary supplement. Picamilon (GABA + niacin) banned as supplement (2015) [1]. || Japan :: GABA is a popular functional food i
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loss at ≥3 g/day [1]. || Australia :: Glucomannan TABLETS banned due to choking hazard [2]. || United States :: Dietary supplement [1]. ||
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Not permitted in NHPs.
Use cautiously in severely immunocompromised patients, ICU patients, and those with central venous catheters — rare cases of probiotic bacteremia and fungemia reported [1].
⚠️ Yellow — use with caution or restricted in some markets
Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients for PMS or carpal tunnel [3]
Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patient warrants IV thiamin [5]
Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective procedures using N₂O [5]
Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Iron supplementation in iron-replete patients may increase cardiovascular and cancer risk — always document deficiency before prescribing [1].
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Union :: Available as food supplement. Subject to novel food regulation in some contexts [1]. || United States (FDA) ::
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Not approved as food supplement. Classified as pharmaceutical.
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Hydroxyanthracene derivatives under assessment.
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Coumarin TDI 0.1 mg/kg BW/day. Cassia type exceeds limits at typical supplement doses.
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ood. Dietary supplement [1]. || European Union :: Novel food ingredient [1]. || South Korea :: Dietary supplement. || Ma
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ood supplement. No authorized health claims. EFSA Novel Food regulation may apply to concentrated extracts [1]. || Japan
Strontium ranelate restricted to severe osteoporosis only. Cardiovascular contraindications.
Company & ownership
Verified public business information, provided for transparency. We publish facts only.
Douglas Laboratories is a practitioner-channel manufacturer. It is part of Atrium Innovations, which Nestlé Health Science acquired in 2017 for $2.3 bn; listed among Nestlé Health Science's VMS brands.
| Established | 1955 · Pittsburgh, Pennsylvania, United States |
| Ownership | Subsidiary |
| Parent corporation | Nestlé Health Science (via Atrium Innovations, acquired 2017) |
| Public / private | Private (parent Nestlé S.A. publicly traded) |
| Stock listing | Parent: Nestlé S.A. (SIX: NESN) |
| Headquarters | Pittsburgh, Pennsylvania, USA |
| Market / revenue | Atrium Innovations VMS assets bought by Nestlé for $2.3 bn (2017) |
Sources: https://www.nestlehealthscience.com/newsroom/press-releases/nestle-completes-acquisition-of-the-bountiful-company-core-brands (lists Douglas Laboratories) | https://www.just-food.com/news/nestle-puts-supplements-assets-on-chopping-block/