✓ No active regulatory warningsFDA, EMA, WHO
📰Read the full St. John's Wort evidence review on GMJ News →Complete clinical article, references and updates on news.gmj.ge. This page is the structured safety summary.ℹ️ Not obtained from food. Not obtained from food in meaningful amounts — supplementation is the practical route.
🔬 Lab interpreter
ℹ️ No validated blood test. There is no established laboratory test to assess status or guide dosing for this ingredient. Clinical response and symptoms are the practical guide.
⚕ For professionals — confirm ranges against your local laboratory.
1 Dosage
📋 Specific dosage data under clinical review. Consult your healthcare provider for personalized guidance.
2 Common questions
What is the recommended dose of St. John's Wort? ▼
The recommended daily allowance is Typical 300 mg × 3/day. The upper tolerable intake level is No UL. Individual requirements may vary based on age, health status, and other factors. Consult your healthcare provider for personalized dosing.
Is St. John's Wort safe to take? ▼
St. John's Wort is classified as "Use with Caution" in the SupplementIndex database. As with any supplement, consult your healthcare provider before starting, especially if you take medications or have medical conditions.
Who should avoid St. John's Wort? ▼
Documented contraindications include: Almost any Rx medication, SSRIs/MAOIs, Oral contraceptives. This list may not be exhaustive. Consult your physician.
3 Safety, toxicity & adverse events
4 Regulatory
General: Classified as dietary supplement in most jurisdictions. Country-specific regulatory data under review.
5 Cite this page
Vancouver: Pkhakadze G. St. John's Wort — safety profile [Internet]. Tbilisi: PHIG; 2026 [cited 2026 Sep 01]. Available from: https://supplement.ge/ingredients/st-johns-wort/
APA 7th: Pkhakadze, G. (2026). St. John's Wort — Safety profile. Public Health Institute of Georgia. https://supplement.ge/ingredients/st-johns-wort/
📋 Editorial information
Author: Prof. G. Pkhakadze, MD, MPH, PhD
Institution: Public Health Institute of Georgia (PHIG)
Affiliation: David Tvildiani Medical University (DTMU)
First published: January 2026
Last reviewed: 2026-09-01
Next review: March 2027
References: 4 cited sources
COI:
Process: Systematic literature review
📄 License & reuse
Published under Creative Commons Attribution 4.0 International (CC BY 4.0). You may share and adapt for any purpose with attribution.
Pkhakadze G. "St. John's Wort — Safety Profile." SupplementIndex, PHIG, 2026. https://supplement.ge/ingredients/st-johns-wort/ CC BY 4.0.
GP
Prof. G. Pkhakadze, MD, MPH, PhD
Professor of Public Health · Head of Department, DTMU
Editor-in-Chief, Georgian Medical Journal (ISSN 3088-4322)
Chair, Public Health Institute of Georgia · UEMS Public Health Section
Educational and public health purposes. CC BY 4.0. Consult your healthcare provider before starting any supplement. Corrections: info@accreditation.ge. Publisher: PHIG