SAFE
Cascara Sagrada
Rhamnus purshiana standardised
Possibly Safe
V1 Verified
Digestive Herbs
PubMed Studies
2
About
Cascara contains cascarsosides with stimulant laxative effects. Was FDA-approved OTC laxative until 2002.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
📊 Effectiveness
Constipation
Evidence Grade B · 8 studies · n=680
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
👥 Safety by Population
🚫 Contraindications & Warnings
Not for chronic use. Electrolyte imbalance. Pregnancy: avoid. GI inflammation: avoid.
🏷️ Other Names
Rhamnus purshiana standardised