1 Product identity
Ingredient risk
Contains restricted ingredients
50 Plus
BrandGNC Mega Men→Other Combinations Other (e.g. tea bag) 48 ingredients 1 banned 1 high-risk 6 caution DSLD #27160Net contents: 120 Caplet(s)
Target: Adults and Children 4 years and above
DSLD entry: 2013-10-25
2 Ingredients (48)
IngredientGroupSafety
Healthy Aging Free Radical Protection BlendBlend (Combination)—
Green Tea Leaf ExtractGreen Tea—
Black Currant Fruit PowderBlack Currant—
Blueberry fruit powderBlueberry—
Memory Health BlendBlend (Combination)—
LycopeneLycopene—
ZeaxanthinZeaxanthin—
CelluloseCellulose—
Vegetable AcetoglyceridesGlycerides—
Caramel colorColor—
Ethyl VanillinEthylvanillin—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ High-risk ingredient — documented serious harm
Inositol — GDM prevention — 4 g/day from first trimester in high-risk women [2]
⛔ Contains an ingredient banned in ≥1 country
Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
3 Safety cross-reference
Vitamin A — Conditionally Safe
⚠ Teratogenic at high doses
⚠ Hepatotoxic with chronic excess
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Vitamin K — Limited Evidence
⚠ Critical interaction with warfarin
Thiamin — Use with Caution
⚠ Very low toxicity
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Biotin — Generally Safe
⚠ Interferes with troponin and thyroid lab assays
Pantothenic Acid — Limited Evidence
⚠ Diarrhea at very high doses
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Iodine — Conditionally Safe
⚠ Thyroid dysfunction at excess
⚠ Kelp: variable content
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Selenium — Conditionally Safe
⚠ Selenosis >400 mcg
⚠ Diabetes risk at high doses
Copper — Conditionally Safe
⚠ Hepatotoxicity at high doses
Manganese — Conditionally Safe
⚠ Neurotoxicity with chronic excess
Chromium — Conditionally Safe
⚠ Hypoglycemia with diabetes meds
⚠ Rare renal/hepatic toxicity
Molybdenum — Generally Safe
⚠ Very low toxicity
Saw Palmetto — Generally Safe
⚠ Anti-androgenic
⚠ May affect PSA
L-Arginine — Limited Evidence
⚠ Hypotension
⚠ May worsen herpes outbreaks
Alpha-Lipoic Acid — Conditionally Safe
⚠ May lower blood glucose
⚠ May lower thyroid hormones
bilberry — Generally Safe
⚠ May increase bleeding risk at high doses
⚠ May lower blood glucose
Elderberry — Limited Evidence
⚠ Raw berries: cyanogenic glycosides
⚠ Cytokine storm concern
Resveratrol — Conditionally Safe
⚠ Estrogenic activity
⚠ CYP enzyme inhibition
Choline — Generally Safe
⚠ Fishy odor at high doses
Phosphatidylserine — Generally Safe
⚠ May enhance anticoagulant effects
⚠ Soy allergy risk (soy-derived)
Inositol — High risk
⚠ GI disturbance at high doses (>12 g)
⚠ May lower blood glucose
Silicon — Generally Safe
⚠ Very low toxicity
Boron — Conditionally Safe
⚠ Reproductive toxicity in animals
Lutein — Generally Safe
⚠ Harmless skin yellowing at very high doses
Astaxanthin — Generally Safe
⚠ May lower blood pressure
Vanadium — Limited Evidence
⚠ GI toxicity: nausea, vomiting, diarrhea
⚠ Green tongue
Titanium Dioxide — Banned in ≥1 country
⚠ EFSA: can no longer be considered safe as food additive (2021)
⚠ Genotoxicity concern (nanoparticles)
4 Label claims
• Nutrient
• All Other
• Structure/Function
5 Data source
DSLD ID27160
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2013-10-25
6 More from GNC Mega Men
View GNC Mega Men Safety Scorecard → 80 products
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Vancouver
Pkhakadze G. 50 Plus — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jun 24]. Available from: https://supplement.ge/products/50-plus-27160/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
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Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG