1 Product identity

Ingredient risk

Contains restricted ingredients

Refine

Name: Refine
Brand: GNC Beyond Raw

BrandGNC Beyond Raw→Other Combinations Capsule 45 ingredients 1 banned 5 caution DSLD #28986

Net contents: 90 Capsule(s)

Target: Adults and Children 4 years and above

DSLD entry: 2014-01-24

2 Ingredients (45)

IngredientGroupSafety

Vitamin CVitamin CGenerally Safe

NiacinNiacinConditionally Safe

Vitamin B6Vitamin B6Use with Caution

Pantothenic AcidPantothenic Acid (Vitamin B5)—

MagnesiumMagnesiumUse with Caution

ZincZincUse with Caution

SodiumSodiumConditionally Safe

PotassiumPotassiumConditionally Safe

Stamina SpikeBlend (Combination)—

Quercetin DihydrateQuercetinConditionally Safe

Ginger root extractGinger —

Schisandra fruit extractSchisandraGenerally Safe

Grape seed extractGrape —

Grape skin extractGrape —

Yerba Mate leaf extractMate—

Black Tea leaf extractBlack Tea—

Dill Weed extractDill—

Herbal Anabolic PotentiatorBlend (Herb/Botanical)—

Fenugreek seed extractFenugreekConditionally Safe

Rhodiola rosea root extractRhodiola Conditionally Safe

Yohimbe bark extractYohimbe—

Thermo Activator BlendBlend (Combination)—

Caffeine AnhydrousCaffeineUse with Caution

Cinnamon powderCinnamonUse with Caution

L-CarnitineL-CarnitineGenerally Safe

Capsimax(TM) Fruit ExtractCapsicum—

Bioperine Black Pepper extractBlack Pepper—

Muscle Stimulator BlendBlend (Combination)—

White Willow bark extractWhite Willow—

Prickley Pear Cactus Leaf ExtractPrickly Pear Cactus—

Cloves bud powderClove—

N-Acetyl-L-CysteineN-Acetyl Cysteine—

D-GlucuronolactoneGlucuronolactone—

TaurineTaurineGenerally Safe

L-TyrosineTyrosine—

Green Tea leaf extractGreen Tea—

N.O. MagnifierBlend (Combination)—

CarnoSynBeta-AlanineGenerally Safe

resVida Trans-ResveratrolResveratrolConditionally Safe

GelatinGelatin—

CelluloseCellulose—

Titanium DioxideTitanium DioxideBanned in ≥1 country

MicaMica—

FD&C Red #40Color—

FD&C Blue #1Color—

Ingredient amounts require the full DSLD label. View full label at NIH DSLD →

⛔ Contains an ingredient banned in ≥1 country

Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.

⚠️ Use with caution — restricted in some markets

Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…

Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].

Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].

Caffeine (Anhydrous) 🇬🇧 🇪🇺 🇦🇺 — High caffeine warnings mandatory on products >150 mg/L.

Cinnamon 🇪🇺 — Coumarin TDI 0.1 mg/kg BW/day. Cassia type exceeds limits at typical supplement doses.

3 Safety cross-reference

Vitamin C — Generally Safe

⚠ GI distress at high doses

⚠ Kidney stones risk >1g/day

Niacin — Conditionally Safe

⚠ Flushing at >50 mg

⚠ Hepatotoxicity at high doses

Vitamin B6 — Use with Caution

Pantothenic Acid — Limited Evidence

⚠ Diarrhea at very high doses

Magnesium — Use with Caution

⚠ Diarrhea (especially oxide)

⚠ Accumulates in renal impairment

Zinc — Use with Caution

⚠ Copper deficiency at >40 mg/day

⚠ Nausea, metallic taste

Sodium — Conditionally Safe

⚠ Hypertension

⚠ Fluid retention

Potassium — Conditionally Safe

⚠ Hyperkalemia risk

⚠ Dangerous with ACE inhibitors

Quercetin — Conditionally Safe

⚠ Inhibits CYP3A4

⚠ Affects cyclosporine levels

Ginger Root — Limited Evidence

⚠ GI: heartburn at high doses

⚠ Antiplatelet effect

Schisandra — Generally Safe

⚠ GI discomfort

⚠ May affect CYP enzymes

Grape Seed Extract — Limited Evidence

⚠ Antiplatelet effect

⚠ May interact with anticoagulants

Fenugreek — Conditionally Safe

⚠ Hypoglycemia

⚠ Maple syrup odor

Rhodiola — Conditionally Safe

⚠ Insomnia if taken late

⚠ MAOI-like activity

Caffeine (Anhydrous) — Use with Caution

Cinnamon — Use with Caution

⚠ Cassia: high coumarin (hepatotoxic)

⚠ May lower glucose

L-Carnitine — Generally Safe

⚠ Fishy body odor

⚠ TMAO concern

White Willow Bark — Limited Evidence

⚠ Contains salicin (aspirin-like)

⚠ GI irritation

Taurine — Generally Safe

⚠ May lower blood pressure

L-Tyrosine — Limited Evidence

⚠ May worsen hyperthyroidism

⚠ Migraine trigger in some

Beta-Alanine — Generally Safe

⚠ Tingling (paraesthesia) — harmless

Resveratrol — Conditionally Safe

⚠ Estrogenic activity

⚠ CYP enzyme inhibition

Titanium Dioxide — Banned in ≥1 country

⚠ EFSA: can no longer be considered safe as food additive (2021)

⚠ Genotoxicity concern (nanoparticles)

4 Label claims

• All Other

• Structure/Function

5 Data source

DSLD ID28986

Full labelView at NIH DSLD →

SourceOffice of Dietary Supplements, NIH

Market statusOn market

Entry date2014-01-24

6 More from GNC Beyond Raw

View GNC Beyond Raw Safety Scorecard → 40 products

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7 Cite this page

Vancouver

Pkhakadze G. Refine — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jul 17]. Available from: https://supplement.ge/products/refine-28986/

CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.

Analyzed by SupplementIndex

PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD

Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG