SAFE

Grape Seed Extract

grape-seed-extract
Possibly Safe V1 Verified
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PubMed Studies
67
PubChem CID
About

Oligomeric proanthocyanidins act as antioxidants; strengthen capillary walls; anti-inflammatory

How it works (mechanism of action)

Used for venous insufficiency, oedema and antioxidant support. Common French pharmacy ingredient especially for vascular conditions.

📊 Effectiveness
Antioxidant
Evidence Grade B · 18 studies · n=2,200
Possibly Effective
Blood pressure
Evidence Grade B · 14 studies · n=1,600
Possibly Effective
Venous insufficiency
Evidence Grade B · 12 studies · n=1,200
Possibly Effective

Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralPossibly safeNot established
PregnancyPossibly safeNot established
ElderlyPossibly safeNot established
🚫 Contraindications & Warnings

Consult a healthcare professional before use if pregnant, breastfeeding, taking prescription medications, or if you have a medical condition. Keep out of reach of children.

🏷️ Other Names
OPC Oligomeric proanthocyanidins Vitis vinifera extract
Updated: 2026-04-11
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