1 Product identity
Ingredient risk
Contains a high-risk ingredient
PaleoCleanse Functional Detoxification Powder
BrandDesigns for Health→Other Combinations Powder 58 ingredients 1 high-risk 7 caution DSLD #23240Net contents: 756 Gram(s)
Target: Adults and Children 4 years and above
DSLD entry: 2013-06-25
2 Ingredients (58)
IngredientGroupSafety
CaloriesCalories—
Calories from FatCalories—
Total FatFat (unspecified)—
Total CarbohydratesCarbohydrate—
SugarSugar—
ProteinProtein (unspecified)—
L-ThreonineTHREONINE—
L-CysteineCysteine—
N-Acetyl-CysteineN-Acetyl Cysteine—
CelandineCelandine—
Dandelion extractDandelion—
Fringe TreeFringetree—
Tapioca DextrinDextrin—
natural Berry flavorFlavor—
natural Vanilla flavorVanilla—
Vegetable CelluloseCellulose—
Stevia (leaf) extractStevia—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ High-risk ingredient — documented serious harm
Inositol — GDM prevention — 4 g/day from first trimester in high-risk women [2]
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Iron — Iron supplementation in iron-replete patients may increase cardiovascular and cancer risk — always document deficiency before prescribing [1].
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
3 Safety cross-reference
Sodium — Conditionally Safe
⚠ Hypertension
⚠ Fluid retention
Vitamin A — Limited Evidence
⚠ Teratogenic at high doses
⚠ Hepatotoxic with chronic excess
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Thiamin — Use with Caution
⚠ Very low toxicity
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Limited Evidence
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Biotin — Generally Safe
⚠ Interferes with troponin and thyroid lab assays
Pantothenic Acid — Limited Evidence
⚠ Diarrhea at very high doses
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Calcium d-Glucarate — Generally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Pea protein — Generally Safe
⚠ Lower in methionine
⚠ GI discomfort in some
Iron — Use with Caution
⚠ GI upset, constipation
⚠ Fatal toxicity in children
Phosphorus — Generally Safe
⚠ Excess impairs calcium absorption
Iodine — Conditionally Safe
⚠ Thyroid dysfunction at excess
⚠ Kelp: variable content
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Selenium — Conditionally Safe
⚠ Selenosis >400 mcg
⚠ Diabetes risk at high doses
Copper — Conditionally Safe
⚠ Hepatotoxicity at high doses
Manganese — Conditionally Safe
⚠ Neurotoxicity with chronic excess
Chromium — Conditionally Safe
⚠ Hypoglycemia with diabetes meds
⚠ Rare renal/hepatic toxicity
Molybdenum — Generally Safe
⚠ Very low toxicity
Glycine — Generally Safe
⚠ Well tolerated
L-Lysine — Limited Evidence
⚠ GI discomfort at high doses
⚠ May increase calcium absorption
Quercetin — Conditionally Safe
⚠ Inhibits CYP3A4
⚠ Affects cyclosporine levels
Taurine — Generally Safe
⚠ May lower blood pressure
Milk Thistle — Generally Safe
⚠ Mild GI
⚠ Asteraceae allergy
Choline — Generally Safe
⚠ Fishy odor at high doses
L-Methionine — Limited Evidence
⚠ Raises homocysteine levels
⚠ May promote tumor growth
Inositol — High risk
⚠ GI disturbance at high doses (>12 g)
⚠ May lower blood glucose
Methylsulfonylmethane — Generally Safe
⚠ GI effects
⚠ Headache
Green Tea Extract — Limited Evidence
⚠ HEPATOTOXICITY >800 mg EGCG
⚠ Iron absorption inhibition
Glutathione — Limited Evidence
⚠ Limited oral bioavailability data
⚠ May affect zinc levels
Vanadium — Limited Evidence
⚠ GI toxicity: nausea, vomiting, diarrhea
⚠ Green tongue
4 Label claims
• All Other
5 Data source
DSLD ID23240
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2013-06-25
6 More from Designs for Health
View Designs for Health Safety Scorecard → 261 products
5-HTP Supreme5-HTP Synergy7-KetoAcetyl L-CarnitineAcnutrolAdrenal Complex7 Cite this page
Vancouver
Pkhakadze G. PaleoCleanse Functional Detoxification Powder — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jul 17]. Available from: https://supplement.ge/products/paleocleanse-functional-detoxification-powder-23240/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG