✓ No active regulatory warningsFDA MedWatch, EMA EudraVigilance, WHO VigiBase, WADA Prohibited List · 2026-05-29
📰Read the full Calcium D-Glucarate evidence review on GMJ News →Complete clinical article, references and updates on news.gmj.ge. This page is the structured safety summary.⚠ Zero human RCTs despite marketing claims [2]
⚠ May increase clearance of glucuronidated drugs (acetaminophen, statins, OCPs) [1]
⚠ Mechanism is sound — human evidence is absent [1]
ℹ️ Not obtained from food. Not applicable — this is not obtained from food in meaningful amounts; supplementation is the practical route.
🔬 Lab interpreter
Recommended test
No standard monitoring
No standard monitoring
Reference range / target
N/A
N/A
Urinary glucuronides (research) [1].
Full lab monitoring ↓⚕ For professionals — confirm ranges against your local laboratory.
Clinical verdict
D-glucarate inhibits beta-glucuronidase (mechanism confirmed), theoretically enhancing estrogen/xenobiotic excretion. Animal cancer prevention data are promising. BUT: ZERO human RCTs for any clinical endpoint. May increase clearance of drugs eliminated by glucuronidation (acetaminophen, statins, OCPs). Marketing exceeds evidence [1] [2].
1 How much do I need?
👤 Adults: Specific dosage data under clinical review
👴 Elderly: Specific dosage data under clinical review
🤰 Pregnancy: See guidance
No data. Avoid [1].
👦 Pediatric: See guidance
No data [1].
🏃 Athletes: Standard dose
⚖️ Obesity: Standard dose
Fat-soluble compounds may require dose adjustment in obesity.
🩺 Renal: Consult specialist
Dose adjustment may be needed in renal impairment.
🌱 Vegan: Standard dose
How to take
🍽 Timing: Divided BID [1].
💊 With food: With or without food [1].
🚫 Avoid: May reduce efficacy of glucuronidated drugs [1].
2 Which form?
| Form | Bioavailability | Vegan | Cost |
|---|---|---|---|
| ['Calcium D-glucarate capsules', 'common', '500 mg per capsule. 500–1,500 mg/day [1].'] | Standard | Check label |
3 Common questions
Does D-glucarate 'detox' estrogen? ▼
It inhibits beta-glucuronidase, which theoretically reduces estrogen reabsorption from the gut (enterohepatic recirculation). The mechanism is sound, but HUMAN clinical data confirming meaningful estrogen level changes are absent [1].
Is D-glucarate proven to prevent cancer? ▼
In ANIMALS: yes (breast, prostate, colon models). In HUMANS: zero RCTs. Preclinical promise ≠ clinical proof [2].
Can D-glucarate affect my medications? ▼
Theoretically YES — many drugs are eliminated via glucuronidation. Enhanced glucuronidation = faster drug clearance. This is a significant theoretical interaction for acetaminophen, statins, NSAIDs, and hormonal contraceptives [1].
4 Clinical evidence
Strong
Beta-glucuronidase inhibition by D-glucaric acid: established enzymology [1]. Glucuronidation is a major Phase II detoxification pathway [1]. HIGH
Moderate
Cancer prevention (animal): reduced mammary, prostate, and colon tumors in animal models [2]. Estrogen metabolite excretion: theoretical support from glucuronidation enhancement [1]. MODERATE
Insufficient
5 Safety, toxicity & adverse events
Relative
⚠ May accelerate clearance of glucuronidated drugs (including oral contraceptives, some others) — reducing their levels
⚠ Hormone-sensitive conditions context — discuss with clinician
⚠ Pregnancy and lactation — limited data
🚩 Red flags
● Patient on OCP + D-glucarate — theoretical contraceptive efficacy reduction [1]
● Patient on drugs cleared by glucuronidation — enhanced clearance [1]
6 Interactions
Drug interactions
Glucuronidated drugs (acetaminophen, statins, OCPs, NSAIDs) Moderate
Mechanism: Enhanced glucuronidation → faster drug clearance. [1]
Effect: Potentially reduced drug levels/efficacy. [1]
Action: Monitor drug efficacy. Particularly relevant for OCPs and narrow TI drugs [1].
Supplement synergies
DIM · 100–200 mg DIM
Dual estrogen metabolism: D-glucarate (excretion) + DIM (2:16α ratio shift) [1].
Dual estrogen metabolism: D-glucarate (excretion) + DIM (2:16α ratio shift) [1].
7 Regulatory
United States: Dietary supplement [1].
8 US supplement products
31
on-market products containing Calcium D-Glucarate (NIH DSLD)
Brands carrying Calcium D-Glucarate (19)
Click a brand to see its Calcium D-Glucarate products.
9 Frequently paired with
10 Cite this page
Vancouver: Pkhakadze G. Calcium D-Glucarate — safety profile [Internet]. Tbilisi: PHIG; 2026 [cited 2026 Aug 15]. Available from: https://supplement.ge/ingredients/calcium-d-glucarate/
APA 7th: Pkhakadze, G. (2026). Calcium D-Glucarate — Safety profile. Public Health Institute of Georgia. https://supplement.ge/ingredients/calcium-d-glucarate/
📋 Editorial information
Author: Prof. G. Pkhakadze, MD, MPH, PhD
Institution: Public Health Institute of Georgia (PHIG)
Affiliation: David Tvildiani Medical University (DTMU)
First published: January 2026
Last reviewed: 2026-05-29
Next review: February 2027
References: 2 cited sources
COI: SupplementIndex receives no funding from supplement manufacturers. All content independently authored by PHIG.
Process: Systematic literature review
📄 License & reuse
Published under Creative Commons Attribution 4.0 International (CC BY 4.0). You may share and adapt for any purpose with attribution.
Pkhakadze G. "Calcium D-Glucarate — Safety Profile." SupplementIndex, PHIG, 2026. https://supplement.ge/ingredients/calcium-d-glucarate/ CC BY 4.0.
GP
Prof. G. Pkhakadze, MD, MPH, PhD
Professor of Public Health · Head of Department, DTMU
Editor-in-Chief, Georgian Medical Journal (ISSN 3088-4322)
Chair, Public Health Institute of Georgia · UEMS Public Health Section
Educational and public health purposes. CC BY 4.0. Consult your healthcare provider before starting any supplement. Corrections: info@accreditation.ge. Publisher: PHIG