1 Product identity
Ingredient risk
Contains a high-risk ingredient
Essential-4 Nutrition Pack
BrandDouglas Laboratories→Other Combinations Other (e.g. tea bag) 105 ingredients 1 high-risk 6 caution DSLD #27225Net contents: 30 Pack(s)
Target: Adults and Children 4 years and above
DSLD entry: 2013-11-25
2 Ingredients (105)
IngredientGroupSafety
CaloriesCalories—
Calories from FatCalories—
Total FatFat (unspecified)—
Multi-Strain Probiotic BlendBlend (non-nutrient/non-botanical)—
Streptococcus thermophilusStreptococcus—
Digestive and Prebiotic BlendBlend—
FOSFructo-Oligosaccharides—
Proprietary Organic Fruit and Vegetable BlendProprietary Blend (Herb/Botanical)—
Organic beet powderBeet—
organic Carrot powderCarrot —
organic Black Currant powderBlack Currant—
organic Blueberry powderBlueberry—
organic Broccoli powderBroccoli—
organic Concord Grape powderGrape —
organic Green Cabbage powderCabbage—
organic Collard Greens powderCollard—
organic Mountain Cranberry powderMountain Cranberry (unspecified)—
organic Kale powderKale—
organic Parsley powderParsley—
organic Pomegranate powderPomegranate—
organic Raspberry powderRaspberry (unspecified)—
L-Cysteine/N-Acetyl L-CysteineBlend (Combination)—
BetaineBetaine—
Rose HipsDog Rose—
Lemon BioflavonoidsFlavonoid (mixture)—
GarlicGarlic—
CauliflowerCauliflower —
Green Papaya extractPapaya—
BlackberryBlackberry—
Celery Powdercelery—
Black Radish PowderRadish—
Apricot powderApricot—
PABAPABA—
Red Wine ProanthocyanidinsProanthocyanidins (unspecified)—
HesperidinHesperidin—
RutinRutin—
Glutamic AcidGlutamic Acid—
LycopeneLycopene—
ZeaxanthinZeaxanthin—
Trace ElementsBlend (Combination)—
CelluloseCellulose—
GelatinGelatin—
GlycerinGlycerol—
WaterWater—
Hydroxypropyl MethylcelluloseHypromellose—
Medium Chain TriglyceridesMedium chain triglycerides (MCT)—
Polysorbate 80Polysorbate—
Polyglycerol Fatty Acid EstersPolyglycerols—
citrus oil extractSweet Orange—
EthylcelluloseEthyl Cellulose—
Coconut Oilcoconut oil—
Ammonium HydroxideAmmonia—
Stearic AcidStearic Acid—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ High-risk ingredient — documented serious harm
Inositol — GDM prevention — 4 g/day from first trimester in high-risk women [2]
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
3 Safety cross-reference
Vitamin A — Limited Evidence
⚠ Teratogenic at high doses
⚠ Hepatotoxic with chronic excess
Vitamin C — Limited Evidence
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Thiamin — Use with Caution
⚠ Very low toxicity
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Limited Evidence
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Limited Evidence
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Biotin — Generally Safe
⚠ Interferes with troponin and thyroid lab assays
Pantothenic Acid — Limited Evidence
⚠ Diarrhea at very high doses
Calcium — Limited Evidence
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Iodine — Conditionally Safe
⚠ Thyroid dysfunction at excess
⚠ Kelp: variable content
Magnesium — Limited Evidence
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Selenium — Limited Evidence
⚠ Selenosis >400 mcg
⚠ Diabetes risk at high doses
Copper — Conditionally Safe
⚠ Hepatotoxicity at high doses
Manganese — Conditionally Safe
⚠ Neurotoxicity with chronic excess
Chromium — Conditionally Safe
⚠ Hypoglycemia with diabetes meds
⚠ Rare renal/hepatic toxicity
Molybdenum — Generally Safe
⚠ Very low toxicity
Potassium — Conditionally Safe
⚠ Hyperkalemia risk
⚠ Dangerous with ACE inhibitors
Lactobacillus — Limited Evidence
⚠ Rare sepsis if immunocompromised
⚠ Gas initially
Bifidobacterium — Limited Evidence
⚠ Gas initially
Slippery Elm — Generally Safe
⚠ May slow medication absorption — separate 2h
⚠ GI coating effect
NAC — Limited Evidence
⚠ GI upset
⚠ Rare bronchospasm
Coenzyme Q10 — Limited Evidence
⚠ May reduce warfarin efficacy
⚠ Mild GI effects
Betaine HCl — Limited Evidence
⚠ Heartburn, GI burning if used without protein meals
⚠ Not for those on H. pylori treatment
Spirulina — Limited Evidence
⚠ Contamination risk: microcystins, heavy metals
⚠ Autoimmune stimulation
Chlorella — Generally Safe
⚠ Contamination risk
⚠ May affect warfarin (vitamin K content)
Inositol — High risk
⚠ GI disturbance at high doses (>12 g)
⚠ May lower blood glucose
Choline — Generally Safe
⚠ Fishy odor at high doses
Green Tea Extract — Limited Evidence
⚠ HEPATOTOXICITY >800 mg EGCG
⚠ Iron absorption inhibition
Apple Pectin — Limited Evidence
⚠ Gas, bloating
⚠ May reduce medication absorption
Bromelain — Conditionally Safe
⚠ Increased bleeding risk
⚠ GI upset
Chloride — Limited Evidence
⚠ Co-ingested with sodium
L-Methionine — Limited Evidence
⚠ Raises homocysteine levels
⚠ May promote tumor growth
Lutein — Generally Safe
⚠ Harmless skin yellowing at very high doses
Boron — Conditionally Safe
⚠ Reproductive toxicity in animals
Vanadium — Limited Evidence
⚠ GI toxicity: nausea, vomiting, diarrhea
⚠ Green tongue
Silicon — Generally Safe
⚠ Very low toxicity
Rosemary Extract — Limited Evidence
⚠ Seizure risk at very high doses
⚠ May affect blood glucose
Sodium — Conditionally Safe
⚠ Hypertension
⚠ Fluid retention
4 Label claims
• All Other
5 Data source
DSLD ID27225
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2013-11-25
6 More from Douglas Laboratories
View Douglas Laboratories Safety Scorecard → 788 products
A-Potene 10A-Potene 25A-Retic Natural Herbal FormulaA-Retic Natural Herbal FormulaA.R. FormulaA.R.M.D. Eye Support7 Cite this page
Vancouver
Pkhakadze G. Essential-4 Nutrition Pack — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jun 24]. Available from: https://supplement.ge/products/essential-4-nutrition-pack-27225/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG