1 Product identity
Ingredient risk
Contains a high-risk ingredient
ProFema
BrandPure Essence→Other Combinations Tablet or Pill 68 ingredients 2 high-risk 6 caution DSLD #327528Net contents: 120 Tablet(s)
Target: Adults and Children 4 years and above
DSLD entry: 2025-04-24
2 Ingredients (68)
IngredientGroupSafety
SuperFood ComplexBlend (Combination)—
Oat Grass Juice ExtractOats—
North Atlantic KelpLaminara—
Herbal ExtractsBlend (Combination)—
Chaste Tree Fruit ExtractChastetree—
Kudzu Root ExtractKudzu —
Burdock Root ExtractBurdock —
Asparagus root extractAsparagus—
Eleuthero Root ExtractEleuthero—
Fo-Ti Root ExtractFo-Ti—
White Peony Root ExtractWhite Peony—
Motherwort Whole Herb ExtractMotherwort—
Poria cocos Sclerotia ExtractPoria Mushroom—
Co-NutrientsBlend (Combination)—
Gamma OryzanolGamma oryzanol—
Mixed Tocopherol ComplexVitamin E (mixed tocopherols)—
OctacosanolOctacosanol—
BioflavonoidsFlavonoid (unspecified)—
Hesperidin Methyl ChalconeHesperidin—
RutinRutin—
MineralsBlend (Combination)—
ionic Sea MineralsBlend—
Bamboo Leaf, Stem ExtractBamboo—
Digestive Aids/EnzymesBlend (Non-Nutrient/Non-Botanical)—
ProteaseProteolytic Enzymes (Proteases)—
AmylaseAmylase—
CellulaseCellulase—
LipaseLipase—
InvertaseSucrase—
BioperineBlack Pepper—
Stearic AcidStearic Acid—
CelluloseCellulose—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ High-risk ingredient — documented serious harm
Black Cohosh 🇺🇸 🇦🇺 🇪🇺 — Hepatotoxicity cases including liver failure — limit 6 months [1]
Inositol — GDM prevention — 4 g/day from first trimester in high-risk women [2]
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
3 Safety cross-reference
Vitamin A — Conditionally Safe
⚠ Teratogenic at high doses
⚠ Hepatotoxic with chronic excess
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Vitamin K — Conditionally Safe
⚠ Critical interaction with warfarin
Thiamin — Use with Caution
⚠ Very low toxicity
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Biotin — Generally Safe
⚠ Interferes with troponin and thyroid lab assays
Pantothenic Acid — Limited Evidence
⚠ Diarrhea at very high doses
Choline — Generally Safe
⚠ Fishy odor at high doses
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Iodine — Conditionally Safe
⚠ Thyroid dysfunction at excess
⚠ Kelp: variable content
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Selenium — Conditionally Safe
⚠ Selenosis >400 mcg
⚠ Diabetes risk at high doses
Copper — Conditionally Safe
⚠ Hepatotoxicity at high doses
Manganese — Conditionally Safe
⚠ Neurotoxicity with chronic excess
Chromium — Conditionally Safe
⚠ Hypoglycemia with diabetes meds
⚠ Rare renal/hepatic toxicity
Molybdenum — Generally Safe
⚠ Very low toxicity
Potassium — Conditionally Safe
⚠ Hyperkalemia risk
⚠ Dangerous with ACE inhibitors
Spirulina — Limited Evidence
⚠ Contamination risk: microcystins, heavy metals
⚠ Autoimmune stimulation
Black Cohosh — High risk
⚠ HEPATOTOXICITY (rare but serious)
⚠ Limit to 6 months
Dong Quai — Limited Evidence
⚠ Anticoagulant effect (coumarin)
⚠ Photosensitivity
Wild Yam — Conditionally Safe
⚠ Does NOT convert to progesterone in body despite marketing claims
⚠ Estrogenic effects
Inositol — High risk
⚠ GI disturbance at high doses (>12 g)
⚠ May lower blood glucose
Quercetin — Conditionally Safe
⚠ Inhibits CYP3A4
⚠ Affects cyclosporine levels
Boron — Conditionally Safe
⚠ Reproductive toxicity in animals
Vanadium — Limited Evidence
⚠ GI toxicity: nausea, vomiting, diarrhea
⚠ Green tongue
Lactase — Generally Safe
⚠ Very well tolerated
⚠ Fungal-derived: rare allergy
Silicon — Generally Safe
⚠ Very low toxicity
Sodium — Limited Evidence
⚠ Hypertension
⚠ Fluid retention
L-Leucine — Limited Evidence
⚠ May worsen pellagra
⚠ High doses may impair glucose metabolism
4 Label claims
• Nutrient
• All Other
• Structure/Function
5 Data source
DSLD ID327528
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2025-04-24
6 More from Pure Essence
View Pure Essence Safety Scorecard → 7 products
AllerFreeBreast-DCandexImmunin-6ProstateEssenceTransitions7 Cite this page
Vancouver
Pkhakadze G. ProFema — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Aug 26]. Available from: https://supplement.ge/products/dsld-327528/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG