⛔ Red — banned or high-risk ingredients
Auto-flagged from PHIG regulatory data. Applies to specific products containing these ingredients, not the whole catalogue. Flags show countries named in the source data.
but minimal α-1/α-2 activity (distinguishing it from the banned ephedrine) [1]. Despite widespread use in fat-burners and pre-workouts, c
GDM prevention — 4 g/day from first trimester in high-risk women [2]
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ates (FDA) :: Dietary supplement. Picamilon (GABA + niacin) banned as supplement (2015) [1]. || Japan :: GABA is a popular functional food i
Dog owner not warned about xylitol toxicity — potentially fatal to dogs [1]
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Banned April 2023 following DTU risk assessment. All products withdrawn.
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Hepatotoxicity cases including liver failure — limit 6 months [1]
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France banned TiO₂ in food from January 2020, first EU country.
⚠️ Yellow — use with caution or restricted in some markets
Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients for PMS or carpal tunnel [3]
Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective procedures using N₂O [5]
Iron supplementation in iron-replete patients may increase cardiovascular and cancer risk — always document deficiency before prescribing [1].
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High caffeine warnings mandatory on products >150 mg/L.
Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patient warrants IV thiamin [5]
Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
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Hydroxyanthracene derivatives under assessment.
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Not approved as food supplement. Classified as pharmaceutical.
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Coumarin TDI 0.1 mg/kg BW/day. Cassia type exceeds limits at typical supplement doses.
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ood. Dietary supplement [1]. || European Union :: Novel food ingredient [1]. || South Korea :: Dietary supplement. || Ma
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ood supplement. No authorized health claims. EFSA Novel Food regulation may apply to concentrated extracts [1]. || Japan