1 Product identity
Ingredient risk
Contains a high-risk ingredient
Catalyst
BrandMannatech→Other Combinations Other (e.g. tea bag) 55 ingredients 1 high-risk 7 caution DSLD #37097Net contents: 120 Caplet(s)
Target: Adults and Children 4 years and above
DSLD entry: 2014-12-29
2 Ingredients (55)
IngredientGroupSafety
CaloriesCalories—
Total CarbohydratesCarbohydrate—
Dietary FiberFiber (unspecified)—
Ambroglycin(R)Proprietary Blend (Combination)—
WatercressWatercress—
Green Pea FiberGreen pea fiber—
GingerGinger —
Ambrotose ComplexTBD—
ArabinogalactanArabinogalactan—
Aloe veraAloe—
Ghatti GumGhatti—
Gum TragacanthTragacanth—
Phytonutrient Complex 2Blend (Combination)—
Acerola extractAcerola—
OrangeOrange (unspecified)—
Rice BranRice Bran—
Rose HipsRose (unspecified)—
Alpha Lipoic AcidAlpha Lipoic Acid—
Microcrystalline CelluloseCellulose—
Stearic AcidStearic Acid—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ High-risk ingredient — documented serious harm
Inositol — GDM prevention — 4 g/day from first trimester in high-risk women [2]
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Iron — Iron supplementation in iron-replete patients may increase cardiovascular and cancer risk — always document deficiency before prescribing [1].
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
3 Safety cross-reference
Vitamin A — Limited Evidence
⚠ Teratogenic at high doses
⚠ Hepatotoxic with chronic excess
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin E — Limited Evidence
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Thiamin — Use with Caution
⚠ Very low toxicity
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Biotin — Limited Evidence
⚠ Interferes with troponin and thyroid lab assays
Pantothenic Acid — Limited Evidence
⚠ Diarrhea at very high doses
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Iron — Use with Caution
⚠ GI upset, constipation
⚠ Fatal toxicity in children
Iodine — Conditionally Safe
⚠ Thyroid dysfunction at excess
⚠ Kelp: variable content
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Selenium — Conditionally Safe
⚠ Selenosis >400 mcg
⚠ Diabetes risk at high doses
Copper — Conditionally Safe
⚠ Hepatotoxicity at high doses
Manganese — Conditionally Safe
⚠ Neurotoxicity with chronic excess
Chromium — Conditionally Safe
⚠ Hypoglycemia with diabetes meds
⚠ Rare renal/hepatic toxicity
Molybdenum — Generally Safe
⚠ Very low toxicity
Sodium — Conditionally Safe
⚠ Hypertension
⚠ Fluid retention
Spirulina — Limited Evidence
⚠ Contamination risk: microcystins, heavy metals
⚠ Autoimmune stimulation
NAC — Limited Evidence
⚠ GI upset
⚠ Rare bronchospasm
Choline — Generally Safe
⚠ Fishy odor at high doses
Inositol — High risk
⚠ GI disturbance at high doses (>12 g)
⚠ May lower blood glucose
Soy Protein — Conditionally Safe
⚠ Isoflavones: estrogenic effects debated
⚠ Thyroid function may be affected
Coenzyme Q10 — Limited Evidence
⚠ May reduce warfarin efficacy
⚠ Mild GI effects
Boron — Conditionally Safe
⚠ Reproductive toxicity in animals
Vanadium — Limited Evidence
⚠ GI toxicity: nausea, vomiting, diarrhea
⚠ Green tongue
Silicon — Generally Safe
⚠ Very low toxicity
GLA — Limited Evidence
⚠ May lower seizure threshold
⚠ Borage oil: hepatotoxic unless PA-free
4 Label claims
• All Other
• Structure/Function
5 Data source
DSLD ID37097
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2014-12-29
6 More from Mannatech
View Mannatech Safety Scorecard → 33 products
Advanced AmbroseAdvanced Ambrotose Complex PowderAdvanced Ambrotose Complex PowderAdvanced Ambrotose Complex PowderAmbroStart Orange FlavoredAmbrotose AO7 Cite this page
Vancouver
Pkhakadze G. Catalyst — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jun 24]. Available from: https://supplement.ge/products/catalyst-37097/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG