1 Product identity
Ingredient risk
Contains a high-risk ingredient
Equi-Fem
BrandBiotics Research Corporation→Other Combinations Tablet or Pill 47 ingredients 2 high-risk 7 caution DSLD #21806Net contents: 126 Tablet(s)
Target: Adults and Children 4 years and above
DSLD entry: 2013-05-24
2 Ingredients (47)
IngredientGroupSafety
PABAPABA—
Citrus BioflavonoidsFlavonoid (mixture)—
FRAC(R)Ferulic Acid—
AmylaseAmylase—
ProteaseProteolytic Enzymes (Proteases)—
LipaseLipase—
Neonatal Adrenal Complex ConcentrateAdrenals—
Lamb Pituitary/Hypothalamus ComplexBlend (non-nutrient/non-botanical)—
Ovarian TissueOvary—
Uterine TissueUterus—
Superoxide DismutaseSuperoxide Dismutase—
CatalaseCatalase—
Stearic AcidStearic Acid—
modified Cellulose GumCellulose—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ High-risk ingredient — documented serious harm
Inositol — GDM prevention — 4 g/day from first trimester in high-risk women [2]
Black Cohosh 🇺🇸 🇦🇺 🇪🇺 — Hepatotoxicity cases including liver failure — limit 6 months [1]
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Iron — Iron supplementation in iron-replete patients may increase cardiovascular and cancer risk — always document deficiency before prescribing [1].
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
3 Safety cross-reference
Vitamin A — Limited Evidence
⚠ Teratogenic at high doses
⚠ Hepatotoxic with chronic excess
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Vitamin K — Limited Evidence
⚠ Critical interaction with warfarin
Thiamin — Use with Caution
⚠ Very low toxicity
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Biotin — Generally Safe
⚠ Interferes with troponin and thyroid lab assays
Pantothenic Acid — Generally Safe
⚠ Diarrhea at very high doses
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Iron — Use with Caution
⚠ GI upset, constipation
⚠ Fatal toxicity in children
Iodine — Conditionally Safe
⚠ Thyroid dysfunction at excess
⚠ Kelp: variable content
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Selenium — Conditionally Safe
⚠ Selenosis >400 mcg
⚠ Diabetes risk at high doses
Copper — Conditionally Safe
⚠ Hepatotoxicity at high doses
Manganese — Conditionally Safe
⚠ Neurotoxicity with chronic excess
Chromium — Conditionally Safe
⚠ Hypoglycemia with diabetes meds
⚠ Rare renal/hepatic toxicity
Molybdenum — Generally Safe
⚠ Very low toxicity
Potassium — Conditionally Safe
⚠ Hyperkalemia risk
⚠ Dangerous with ACE inhibitors
Choline — Generally Safe
⚠ Fishy odor at high doses
Inositol — High risk
⚠ GI disturbance at high doses (>12 g)
⚠ May lower blood glucose
Coenzyme Q10 — Limited Evidence
⚠ May reduce warfarin efficacy
⚠ Mild GI effects
L-Tyrosine — Limited Evidence
⚠ May worsen hyperthyroidism
⚠ Migraine trigger in some
Betaine HCl — Limited Evidence
⚠ Heartburn, GI burning if used without protein meals
⚠ Not for those on H. pylori treatment
Black Cohosh — High risk
⚠ HEPATOTOXICITY (rare but serious)
⚠ Limit to 6 months
Dong Quai — Limited Evidence
⚠ Anticoagulant effect (coumarin)
⚠ Photosensitivity
GLA — Limited Evidence
⚠ May lower seizure threshold
⚠ Borage oil: hepatotoxic unless PA-free
4 Label claims
• All Other
5 Data source
DSLD ID21806
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2013-05-24
6 More from Biotics Research Corporation
View Biotics Research Corporation Safety Scorecard → 240 products
5-HTP7-Keto-ZymeA.D.P.Acetyl-L-CarnitineADB5-PlusADHS7 Cite this page
Vancouver
Pkhakadze G. Equi-Fem — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jul 28]. Available from: https://supplement.ge/products/equi-fem-21806/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG