1 Product identity
Ingredient risk
Contains restricted ingredients
50 Plus Mini
BrandGNC Women's Ultra Mega→Other Combinations Tablet or Pill 42 ingredients 1 banned 1 high-risk 7 caution DSLD #47961Net contents: 90 Mini Tablet(s)
Target: Adults and Children 4 years and above
DSLD entry: 2015-07-24
2 Ingredients (42)
IngredientGroupSafety
Brain Health BlendBlend (Combination)—
Eye Health SupportBlend (non-nutrient/non-botanical)—
ZeaxanthinZeaxanthin—
Urinary Tract & Women's Health BlendBlend (Combination)—
Cranberry fruit concentratecranberry—
Skin Structure & Antioxidant SupportBlend (Combination)—
CelluloseCellulose—
Vegetable AcetoglyceridesGlycerides—
Carmine colorColor—
natural Vanilla flavorVanilla—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ High-risk ingredient — documented serious harm
Inositol — GDM prevention — 4 g/day from first trimester in high-risk women [2]
⛔ Contains an ingredient banned in ≥1 country
Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
Collagen Peptides 🇯🇵 — d health claims. Classified as a food supplement (novel food category in some jurisdictions) [2]. || Japan (MHLW) :: Col
3 Safety cross-reference
Vitamin A — Conditionally Safe
⚠ Teratogenic at high doses
⚠ Hepatotoxic with chronic excess
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Vitamin K — Limited Evidence
⚠ Critical interaction with warfarin
Thiamin — Use with Caution
⚠ Very low toxicity
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Biotin — Generally Safe
⚠ Interferes with troponin and thyroid lab assays
Pantothenic Acid — Limited Evidence
⚠ Diarrhea at very high doses
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Iodine — Conditionally Safe
⚠ Thyroid dysfunction at excess
⚠ Kelp: variable content
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Selenium — Conditionally Safe
⚠ Selenosis >400 mcg
⚠ Diabetes risk at high doses
Copper — Conditionally Safe
⚠ Hepatotoxicity at high doses
Manganese — Conditionally Safe
⚠ Neurotoxicity with chronic excess
Chromium — Conditionally Safe
⚠ Hypoglycemia with diabetes meds
⚠ Rare renal/hepatic toxicity
Molybdenum — Generally Safe
⚠ Very low toxicity
Ginkgo Biloba — Limited Evidence
⚠ BLEEDING RISK
⚠ Seizures (ginkgotoxin)
Phosphatidylserine — Generally Safe
⚠ May enhance anticoagulant effects
⚠ Soy allergy risk (soy-derived)
Choline — Generally Safe
⚠ Fishy odor at high doses
Inositol — High risk
⚠ GI disturbance at high doses (>12 g)
⚠ May lower blood glucose
Lutein — Generally Safe
⚠ Harmless skin yellowing at very high doses
Boron — Conditionally Safe
⚠ Reproductive toxicity in animals
Collagen Peptides — Use with Caution
Silicon — Generally Safe
⚠ Very low toxicity
Titanium Dioxide — Banned in ≥1 country
⚠ EFSA: can no longer be considered safe as food additive (2021)
⚠ Genotoxicity concern (nanoparticles)
Sucralose — Conditionally Safe
⚠ May affect gut microbiome
⚠ Heating may produce chlorinated compounds
4 Label claims
• All Other
• Structure/Function
5 Data source
DSLD ID47961
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2015-07-24
6 More from GNC Women's Ultra Mega
View GNC Women's Ultra Mega Safety Scorecard → 53 products
50 PlusBlood Glucose SupportBurn 60Calcium & Vitamin D With MBPCalcium 500Calcium 6007 Cite this page
Vancouver
Pkhakadze G. 50 Plus Mini — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Aug 26]. Available from: https://supplement.ge/products/50-plus-mini-47961/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG