1 Product identity
Ingredient risk
Contains a high-risk ingredient
Bone Builder Active
BrandMetagenics→Other Combinations Tablet or Pill 49 ingredients 1 high-risk 3 caution DSLD #323333Net contents: 180 Tablet(s)
Target: Adults and Children 4 years and above
DSLD entry: 2025-02-23
2 Ingredients (49)
IngredientGroupSafety
Total CarbohydratesCarbohydrate—
Dietary FiberFiber (unspecified)—
Horsetail Aerial Parts ExtractHorsetail—
Microcrystalline CelluloseCellulose—
Citrus Bioflavonoid ComplexFlavonoid—
Alpha-D-RibofuranoseRibose—
Horsetail ExtractHorsetail—
Citric AcidCitric Acid—
Boric AcidBoric acid—
HypromelloseHypromellose—
Medium Chain TriglycerideMedium chain triglycerides (MCT)—
Hydroxypropyl CelluloseHydroxypropyl cellulose—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ High-risk ingredient — documented serious harm
Xylitol — Dog owner not warned about xylitol toxicity — potentially fatal to dogs [1]
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
3 Safety cross-reference
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Phosphorus — Generally Safe
⚠ Excess impairs calcium absorption
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Copper — Conditionally Safe
⚠ Hepatotoxicity at high doses
Manganese — Conditionally Safe
⚠ Neurotoxicity with chronic excess
Chromium — Conditionally Safe
⚠ Hypoglycemia with diabetes meds
⚠ Rare renal/hepatic toxicity
Glucosamine — Limited Evidence
⚠ Shellfish allergy
⚠ May affect glucose
Boron — Conditionally Safe
⚠ Reproductive toxicity in animals
Sodium — Conditionally Safe
⚠ Hypertension
⚠ Fluid retention
Chloride — Limited Evidence
⚠ Co-ingested with sodium
Potassium — Conditionally Safe
⚠ Hyperkalemia risk
⚠ Dangerous with ACE inhibitors
Xylitol — High risk
⚠ GI distress (gas, bloating, diarrhea) dose-dependent
⚠ Cardiovascular risk: 2023 Cleveland Clinic study linked xylitol to increased thrombotic events
Glutathione — Limited Evidence
⚠ Limited oral bioavailability data
⚠ May affect zinc levels
Silicon — Generally Safe
⚠ Very low toxicity
4 Label claims
• Nutrient
• All Other
• Structure/Function
5 Data source
DSLD ID323333
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2025-02-23
6 More from Metagenics
View Metagenics Safety Scorecard → 118 products
ActiFolateAdvaClearArginine PlusAxis Endo Mango FlavorAzeo-PangenAzeo-Pangen7 Cite this page
Vancouver
Pkhakadze G. Bone Builder Active — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jul 17]. Available from: https://supplement.ge/products/dsld-323333/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG