1 Product identity
Ingredient risk
Contains a high-risk ingredient
Cholo-SYN
BrandDouglas Laboratories→Other Combinations Capsule 41 ingredients 1 high-risk 5 caution DSLD #8134Net contents: 120 Capsule(s)
Target: Adults and Children 4 years and above
DSLD entry: 2012-03-23
2 Ingredients (41)
IngredientGroupSafety
Hesperidin ComplexBlend (non-nutrient/non-botanical)—
RutinRutin—
BioflavonoidsFlavonoid (mixture)—
GarlicGarlic—
Omega-3 Marine Lipid Concentrate——
Guar GumGuar—
MucopolysaccharidesMucopolysaccharide—
PectinPectin—
Lecithinlecithin—
BetaineBetaine—
GelatinGelatin—
CelluloseCellulose—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ High-risk ingredient — documented serious harm
Inositol — GDM prevention — 4 g/day from first trimester in high-risk women [2]
⚠️ Use with caution — restricted in some markets
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
3 Safety cross-reference
Vitamin A — Conditionally Safe
⚠ Teratogenic at high doses
⚠ Hepatotoxic with chronic excess
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Thiamin — Use with Caution
⚠ Very low toxicity
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Limited Evidence
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Pantothenic Acid — Generally Safe
⚠ Diarrhea at very high doses
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Iodine — Conditionally Safe
⚠ Thyroid dysfunction at excess
⚠ Kelp: variable content
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Selenium — Conditionally Safe
⚠ Selenosis >400 mcg
⚠ Diabetes risk at high doses
Copper — Conditionally Safe
⚠ Hepatotoxicity at high doses
Manganese — Conditionally Safe
⚠ Neurotoxicity with chronic excess
Chromium — Conditionally Safe
⚠ Hypoglycemia with diabetes meds
⚠ Rare renal/hepatic toxicity
Molybdenum — Generally Safe
⚠ Very low toxicity
Potassium — Conditionally Safe
⚠ Hyperkalemia risk
⚠ Dangerous with ACE inhibitors
Vanadium — Limited Evidence
⚠ GI toxicity: nausea, vomiting, diarrhea
⚠ Green tongue
Boron — Conditionally Safe
⚠ Reproductive toxicity in animals
L-Carnitine — Generally Safe
⚠ Fishy body odor
⚠ TMAO concern
Taurine — Generally Safe
⚠ May lower blood pressure
Choline — Generally Safe
⚠ Fishy odor at high doses
Inositol — High risk
⚠ GI disturbance at high doses (>12 g)
⚠ May lower blood glucose
L-Methionine — Limited Evidence
⚠ Raises homocysteine levels
⚠ May promote tumor growth
Bromelain — Conditionally Safe
⚠ Increased bleeding risk
⚠ GI upset
4 Label claims
• All Other
5 Data source
DSLD ID8134
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2012-03-23
6 More from Douglas Laboratories
View Douglas Laboratories Safety Scorecard → 788 products
A-Potene 10A-Potene 25A-Retic Natural Herbal FormulaA-Retic Natural Herbal FormulaA.R. FormulaA.R.M.D. Eye Support7 Cite this page
Vancouver
Pkhakadze G. Cholo-SYN — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Aug 25]. Available from: https://supplement.ge/products/cholo-syn-8134/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG