1 Product identity
Ingredient risk
3 ingredients to use with caution
CAL Calcium Plus
BrandSystemic Formulas Bio Nutriment→Other Combinations Capsule 16 ingredients 3 caution DSLD #22216Net contents: 100 Capsule(s)
Target: Adults and Children 4 years and above
DSLD entry: 2013-06-25
2 Ingredients (16)
IngredientGroupSafety
Lecithinlecithin—
Aspartic AcidAspartic Acid—
Proprietary BlendProprietary Blend (Combination)—
GelatinGelatin—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Iron — Iron supplementation in iron-replete patients may increase cardiovascular and cancer risk — always document deficiency before prescribing [1].
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
3 Safety cross-reference
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Iron — Use with Caution
⚠ GI upset, constipation
⚠ Fatal toxicity in children
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Copper — Conditionally Safe
⚠ Hepatotoxicity at high doses
Potassium — Conditionally Safe
⚠ Hyperkalemia risk
⚠ Dangerous with ACE inhibitors
L-Lysine — Limited Evidence
⚠ GI discomfort at high doses
⚠ May increase calcium absorption
L-Methionine — Limited Evidence
⚠ Raises homocysteine levels
⚠ May promote tumor growth
Chloride — Limited Evidence
⚠ Co-ingested with sodium
Boron — Conditionally Safe
⚠ Reproductive toxicity in animals
4 Label claims
• All Other
• Structure/Function
5 Data source
DSLD ID22216
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2013-06-25
6 More from Systemic Formulas Bio Nutriment
ABC Acidophilus, Bifidus And Bulgaricus ComplexACP Vitamin ACPACX Vitamin DTXAZV Multi VitaminBFO Borage/Fish/Flax OilsBSV Vitamin B Stress Complex7 Cite this page
Vancouver
Pkhakadze G. CAL Calcium Plus — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Aug 25]. Available from: https://supplement.ge/products/cal-calcium-plus-22216/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG