1 Product identity

Ingredient risk

4 ingredients to use with caution

Amplified N.O. Loaded Fruit Punch

Name: Amplified N.O. Loaded Fruit Punch
Brand: GNC Pro Performance AMP Advanced Muscle Performance

BrandGNC Pro Performance AMP Advanced Muscle Performance→Other Combinations Powder 46 ingredients 4 caution DSLD #4290

Net contents: 2.18 lb

Target: Adults and Children 4 years and above

DSLD entry: 2012-01-25

2 Ingredients (46)

IngredientGroupSafety

CaloriesCalories—

Total CarbohydratesCarbohydrate—

SugarSugar—

ThiamineThiaminUse with Caution

RiboflavinRiboflavinGenerally Safe

NiacinNiacinConditionally Safe

Vitamin B6Vitamin B6Use with Caution

Folic AcidFolateConditionally Safe

Vitamin B12Vitamin B12Use with Caution

BiotinBiotinGenerally Safe

Pantothenic AcidPantothenic AcidGenerally Safe

CalciumCalciumConditionally Safe

PhosphorusPhosphorusGenerally Safe

PotassiumPotassiumConditionally Safe

Tri-MG AcceleratorProprietary Blend (Combination)—

BetaineBetaine—

Beta-AlanineBeta-AlanineGenerally Safe

Branched Chain Amino Acid BlendBlend (Amino Acid/Protein)—

L-LeucineLeucine—

L-IsoleucineIsoleucine—

L-ValineValine—

N.O. Charge BlendBlend (Combination)—

L-ArginineArginine—

L-Citrulline MalateCitrulline malateGenerally Safe

Yohimbe bark powderYohimbe—

Mega Natural-BP Grape seed extractGrape —

Creatine Matrix BlendBlend (Combination)—

DiCreatine MalateCreatine Malate—

Creatine Ethyl Ester HClCreatineGenerally Safe

GuanidinoacetateGlycocyamine—

Creatine AKGCreatine alpha-ketoglutarate—

L-ArginineArginine—

L-GlycineGlycineGenerally Safe

L-MethionineMETHIONINE—

EFAMBlend (Combination)—

Caffeine AnhydrousCaffeineUse with Caution

Medium Chain TriglyceridesMedium chain triglycerides (MCT)—

L-CarnitineL-CarnitineGenerally Safe

Citric AcidCitric Acid—

Natural and Artificial flavorsFlavor—

Malic AcidMalic Acid—

Calcium SilicateCalcium Silicate—

Silicon DioxideSiliconGenerally Safe

SucraloseSucraloseConditionally Safe

Acesulfame PotassiumAcesulfame potassium—

FD&C Red #40Color—

Ingredient amounts require the full DSLD label. View full label at NIH DSLD →

⚠️ Use with caution — restricted in some markets

Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…

Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…

Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…

Caffeine (Anhydrous) 🇬🇧 🇪🇺 🇦🇺 — High caffeine warnings mandatory on products >150 mg/L.

3 Safety cross-reference

Thiamin — Use with Caution

⚠ Very low toxicity

Riboflavin — Generally Safe

⚠ Harmless yellow urine

Niacin — Conditionally Safe

⚠ Flushing at >50 mg

⚠ Hepatotoxicity at high doses

Vitamin B6 — Use with Caution

Folate — Conditionally Safe

⚠ May mask B12 deficiency

⚠ Colorectal cancer risk debated

Vitamin B12 — Use with Caution

Biotin — Generally Safe

⚠ Interferes with troponin and thyroid lab assays

Pantothenic Acid — Generally Safe

⚠ Diarrhea at very high doses

Calcium — Conditionally Safe

⚠ Cardiovascular risk debated >1,000 mg/day

⚠ Kidney stones

Phosphorus — Generally Safe

⚠ Excess impairs calcium absorption

Potassium — Conditionally Safe

⚠ Hyperkalemia risk

⚠ Dangerous with ACE inhibitors

Beta-Alanine — Generally Safe

⚠ Tingling (paraesthesia) — harmless

L-Leucine — Limited Evidence

⚠ May worsen pellagra

⚠ High doses may impair glucose metabolism

L-Arginine — Limited Evidence

⚠ Hypotension

⚠ May worsen herpes outbreaks

Citrulline malate — Generally Safe

⚠ May lower blood pressure

Grape Seed Extract — Limited Evidence

⚠ Antiplatelet effect

⚠ May interact with anticoagulants

Creatine — Limited Evidence

⚠ Water retention

⚠ Weight gain

Glycine — Generally Safe

⚠ Well tolerated

L-Methionine — Limited Evidence

⚠ Raises homocysteine levels

⚠ May promote tumor growth

Caffeine (Anhydrous) — Use with Caution

L-Carnitine — Generally Safe

⚠ Fishy body odor

⚠ TMAO concern

Silicon — Generally Safe

⚠ Very low toxicity

Sucralose — Conditionally Safe

⚠ May affect gut microbiome

⚠ Heating may produce chlorinated compounds

4 Label claims

• Nutrient

• All Other

• Structure/Function

5 Data source

DSLD ID4290

Full labelView at NIH DSLD →

SourceOffice of Dietary Supplements, NIH

Market statusOn market

Entry date2012-01-25

6 More from GNC Pro Performance AMP Advanced Muscle Performance

View GNC Pro Performance AMP Advanced Muscle Performance Safety Scorecard → 9 products

Amplified 100% Whey Protein Vanilla Amplified Muscle Igniter 4X Tropical Punch Amplified N.O. Loaded Blue Raspberry Amplified Wheybolic Extreme 60 Fruit Punch CLA Mega Men Sport (Full Strength)

7 Cite this page

Vancouver

Pkhakadze G. Amplified N.O. Loaded Fruit Punch — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jun 18]. Available from: https://supplement.ge/products/amplified-n-o-loaded-fruit-punch-4290/

CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.

Analyzed by SupplementIndex

PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD

Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG