1 Product identity
Ingredient risk
Contains restricted ingredients
Active-Male Brain Awake MAX3 + Nitric Oxide Booster
BrandIrwin Naturals→Other Combinations Softgel Capsule 33 ingredients 1 banned 4 caution DSLD #323275Net contents: 60 Liquid Soft-Gel(s)
Target: Adults and Children 4 years and above
DSLD entry: 2025-03-25
2 Ingredients (33)
IngredientGroupSafety
CaloriesCalories—
Total FatFat (unspecified)—
CholesterolCholesterol—
Total CarbohydratesCarbohydrate—
ProteinProtein—
Holy Basil Herb ExtractHoly Basil—
InnovaTeaTea (unspecified)—
BioPerine ComplexBlend—
BioPerineBlack Pepper—
Ginger Rhizome ExtractGinger —
GelatinGelatin—
Water, PurifiedWater—
GlycerinGlycerol—
AnnattoAnnatto—
BeeswaxBeeswax—
MannitolMannitol—
Sunflower Lecithinlecithin—
Medium Chain Triglyceride OilMedium chain triglycerides (MCT)—
MaltodextrinMaltodextrin—
Soy Lecithinlecithin—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ Contains an ingredient banned in ≥1 country
Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Caffeine (Anhydrous) 🇬🇧 🇪🇺 🇦🇺 — High caffeine warnings mandatory on products >150 mg/L.
3 Safety cross-reference
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin B6 — Use with Caution
Vitamin B12 — Use with Caution
Citrulline Malate — Generally Safe
⚠ May lower blood pressure
L-Carnitine — Limited Evidence
⚠ Fishy body odor
⚠ TMAO concern
Ginkgo Biloba — Limited Evidence
⚠ BLEEDING RISK
⚠ Seizures (ginkgotoxin)
L-Theanine — Limited Evidence
⚠ May enhance sedatives
Caffeine (Anhydrous) — Use with Caution
Gotu Kola — Conditionally Safe
⚠ Hepatotoxicity (rare)
⚠ Drowsiness
Phosphatidylserine — Generally Safe
⚠ May enhance anticoagulant effects
⚠ Soy allergy risk (soy-derived)
Titanium Dioxide — Banned in ≥1 country
⚠ EFSA: can no longer be considered safe as food additive (2021)
⚠ Genotoxicity concern (nanoparticles)
Silicon — Generally Safe
⚠ Very low toxicity
4 Label claims
• Nutrient
• All Other
• Structure/Function
5 Data source
DSLD ID323275
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2025-03-25
6 More from Irwin Naturals
View Irwin Naturals Safety Scorecard → 24 products
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Vancouver
Pkhakadze G. Active-Male Brain Awake MAX3 + Nitric Oxide Booster — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Aug 26]. Available from: https://supplement.ge/products/active-male-brain-awake-max3-nitric-oxide-booster-323275/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG