1 Product identity

Ingredient risk

Contains restricted ingredients

2-in-1 Cleanse & Flush

Name: 2-in-1 Cleanse & Flush
Brand: Irwin Naturals

BrandIrwin Naturals→Other Combinations Softgel Capsule 30 ingredients 1 banned 2 caution DSLD #323273

Net contents: 60 Liquid Softgel(s)

Target: Adults and Children 4 years and above

DSLD entry: 2025-01-23

2 Ingredients (30)

IngredientGroupSafety

CaloriesCalories—

Total FatFat (unspecified)—

Total CarbohydratesCarbohydrate—

ProteinProtein—

ChromiumChromiumConditionally Safe

Extra Virgin Olive OilOlive Oil—

Milk Thistle Seed ExtractMilk ThistleGenerally Safe

Cascara Sagrada Bark ExtractCascara SagradaUse with Caution

Cinnamon Bark ExtractCinnamonUse with Caution

Gymnema leaf extractGymnemaConditionally Safe

Cardamom Fruit ExtractCardamom—

Lemon Balm Aerial Extractlemon balm—

Marshmallow Root ExtractMarshmallow —

Turmeric Root ExtractTurmericConditionally Safe

CurcuminoidsCurcuminoids—

BioPerine ComplexBlend—

BioPerineBlack Pepper—

Ginger Rhizome ExtractGinger —

GelatinGelatin—

Water, PurifiedWater—

GlycerinGlycerol—

BeeswaxBeeswax—

DextrinDextrin—

Soy Lecithinlecithin—

TurmericTurmericConditionally Safe

MaltodextrinMaltodextrin—

Titanium DioxideTitanium DioxideBanned in ≥1 country

RiboflavinRiboflavinGenerally Safe

Silicon DioxideSiliconGenerally Safe

Sodium Copper ChlorophyllinSodiumConditionally Safe

Ingredient amounts require the full DSLD label. View full label at NIH DSLD →

⛔ Contains an ingredient banned in ≥1 country

Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.

⚠️ Use with caution — restricted in some markets

Cascara Sagrada 🇪🇺 — Hydroxyanthracene derivatives under assessment.

Cinnamon 🇪🇺 — Coumarin TDI 0.1 mg/kg BW/day. Cassia type exceeds limits at typical supplement doses.

3 Safety cross-reference

Chromium — Conditionally Safe

⚠ Hypoglycemia with diabetes meds

⚠ Rare renal/hepatic toxicity

Milk Thistle — Generally Safe

⚠ Mild GI

⚠ Asteraceae allergy

Cascara Sagrada — Use with Caution

⚠ Stimulant laxative — same chronic abuse risk as senna

⚠ Electrolyte imbalance

Cinnamon — Use with Caution

⚠ Cassia: high coumarin (hepatotoxic)

⚠ May lower glucose

Gymnema — Conditionally Safe

⚠ Hypoglycemia with diabetes meds

⚠ Temporarily suppresses sweet taste

Marshmallow Root — Limited Evidence

⚠ May slow medication absorption — take 2h apart

⚠ May lower blood glucose

Titanium Dioxide — Banned in ≥1 country

⚠ EFSA: can no longer be considered safe as food additive (2021)

⚠ Genotoxicity concern (nanoparticles)

Riboflavin — Generally Safe

⚠ Harmless yellow urine

Silicon — Generally Safe

⚠ Very low toxicity

Sodium — Conditionally Safe

⚠ Hypertension

⚠ Fluid retention

4 Label claims

• Nutrient

• All Other

• Structure/Function

5 Data source

DSLD ID323273

Full labelView at NIH DSLD →

SourceOffice of Dietary Supplements, NIH

Market statusOn market

Entry date2025-01-23

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View Irwin Naturals Safety Scorecard → 24 products

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7 Cite this page

Vancouver

Pkhakadze G. 2-in-1 Cleanse & Flush — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Aug 25]. Available from: https://supplement.ge/products/2-in-1-cleanse-flush-323273/

CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.

Analyzed by SupplementIndex

PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD

Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG