✓ No active regulatory warningsFDA MedWatch, EMA EudraVigilance, WHO VigiBase, WADA Prohibited List · 2026-05-29
Updated: 2026-05-29 · v2.0 · Prof. G. Pkhakadze, MD, MPH, PhDCiteEditorial
1
Safe
Magnesium Malate
Magnesium malate
Generally SafeModerateMajor Minerals
RDA
Typical 200–400 mg elem. Mg
Target
—
Upper limit
350 mg
Products
8
Dosage by population group — reference
🔗 Best with: Vitamin D, Calcium, Vitamin B6✅ USP Verified, NSF Contents Certified, Clean Label Project Certified
⚠ Fibromyalgia evidence: single small pilot study only [2]
⚠ Malic acid 'energy' theory is biochemically plausible but clinically unproven [1]
⚠ See Mg Glycinate entry for form comparison [1]
🥗 Food first — build your daily Typical 200–400 mg elem. Mg
Check the foods you regularly eat — the bar fills toward your daily target.
0 mg
Check your regular foods above
🔬 Lab interpreter
Recommended test
See Mg entry
Reference range / target
[1]
When to test
[1]
Full lab monitoring ↓
⚕ For professionals — confirm ranges against your local laboratory.
Clinical verdict
Mg malate: good absorption + malic acid (Krebs cycle). Often recommended for fibromyalgia/fatigue but evidence is ONE small pilot study. For sleep: glycinate. For brain: threonate. For constipation: citrate. For energy/fibromyalgia: malate (theoretical basis, weak clinical data) [1] [2].
1 Am I deficient?
Not applicable0%

What happens as status declines

Not applicable
Not an essential nutrient [1].

Risk factors

• Not applicable — not an essential nutrient [1]
🧬 How Magnesium Malate works ▼
This form delivers magnesium — a cofactor for over 300 enzymes including ATP synthesis — bound to malic acid, an intermediate of the citric-acid cycle. It is marketed for energy and fibromyalgia/fatigue, with the malate component proposed to support aerobic energy production; absorption is good and the laxative effect is modest.
2 How much do I need?
👤 Adults: Specific dosage data under clinical review
👴 Elderly: Specific dosage data under clinical review
🤰 Pregnancy: See guidance
See Magnesium entry [1].
👦 Pediatric: See guidance
See Mg entry [1].
🏃 Athletes: Standard dose
⚖️ Obesity: Standard dose
Fat-soluble compounds may require dose adjustment in obesity.
🩺 Renal: Consult specialist
Dose adjustment may be needed in renal impairment.
🌱 Vegan: Standard dose

How to take

🍽 Timing: Any time. Split BID [1].
💊 With food: With or without food [1].
🚫 Avoid: See Mg entry [1].
3 Which form?
FormBioavailabilityVeganCost
['Magnesium malate tablets/capsules', 'common', 'Standard. Well-tolerated [1].']StandardCheck label
4 Common questions
Malate vs glycinate vs citrate? ▼
Malate: good absorption, mild laxative, malic acid energy theory. Glycinate: best-tolerated (least laxative), calming glycine. Citrate: good absorption, moderate laxative. Threonate: brain-specific. Choose based on primary goal [1].
Does malic acid really help energy? ▼
Malic acid IS a Krebs cycle intermediate, but oral supplementation's impact on cellular ATP production is NOT established. The fibromyalgia pilot study was small and not replicated [1] [2].
5 Clinical evidence

Strong

Malic acid is a Krebs cycle intermediate — basic biochemistry [1]. Good Mg absorption [1]. HIGH

Moderate

Fibromyalgia: one small pilot study (n=24) showed reduced pain and tenderness with Mg malate (weak evidence) [2]. MODERATE

Insufficient

Chronic fatigue [1]. Energy enhancement beyond Mg repletion [1]. Direct comparison to other Mg forms for clinical outcomes [1]. LOW
6 Safety, toxicity & adverse events

Absolute contraindications

✕ Severe renal failure (GFR <30) — hypermagnesemia risk

Relative

⚠ Myasthenia gravis
⚠ Heart block
⚠ Separate from bisphosphonates, tetracyclines and quinolones

🚩 Red flags

● See Magnesium entry [1]
7 Interactions

Supplement synergies

See Mg entry · [1]
[1]
8 Laboratory monitoring
See Mg entry Primary
Target: [1] · [1]
9 US supplement products
8
on-market products containing Magnesium Malate (NIH DSLD)

Brands carrying Magnesium Malate (8)

Click a brand to see its Magnesium Malate products.
Or browse all 8 products in one list →
10 Frequently paired with
Magnesium 7 sharedBiotin 2 sharedCalcium 2 shared
Magnesium Malate vs Vitamin DMagnesium Malate vs Calcium
11 References (2)
[1]National Institutes of Health, ODS. Magnesium. Updated 2024. ods.od.nih.gov REVIEW Accessed: 2026-05-29
[2]Russell IJ, et al. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol. 1995;22(5):953-958. RCT Accessed: 2026-05-29
12 Related articles
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Auto-populated from GMJ Newsroom. Articles tagged "Magnesium Malate".
13 Cite this page
Vancouver: Pkhakadze G. Magnesium Malate — safety profile [Internet]. Tbilisi: PHIG; 2026 [cited 2026 Jun 02]. Available from: https://supplement.ge/ingredients/magnesium-malate/
APA 7th: Pkhakadze, G. (2026). Magnesium Malate — Safety profile. Public Health Institute of Georgia. https://supplement.ge/ingredients/magnesium-malate/
📋 Editorial information
Author: Prof. G. Pkhakadze, MD, MPH, PhD
Institution: Public Health Institute of Georgia (PHIG)
Affiliation: David Tvildiani Medical University (DTMU)
First published: January 2026
Last reviewed: 2026-05-29
Next review: December 2026
References: 2 cited sources
COI: SupplementIndex receives no funding from supplement manufacturers. All content independently authored by PHIG.
Process: Systematic literature review
📄 License & reuse
Published under Creative Commons Attribution 4.0 International (CC BY 4.0). You may share and adapt for any purpose with attribution.
Pkhakadze G. "Magnesium Malate — Safety Profile." SupplementIndex, PHIG, 2026. https://supplement.ge/ingredients/magnesium-malate/ CC BY 4.0.
GP
Prof. G. Pkhakadze, MD, MPH, PhD
Professor of Public Health · Head of Department, DTMU
Editor-in-Chief, Georgian Medical Journal (ISSN 3088-4322)
Chair, Public Health Institute of Georgia · UEMS Public Health Section
Educational and public health purposes. CC BY 4.0. Consult your healthcare provider before starting any supplement. Corrections: info@accreditation.ge. Publisher: PHIG