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Updated: 2026-05-29 · v2.0 · Prof. G. Pkhakadze, MD, MPH, PhDCiteEditorial
📰Read the full Magnesium L-Threonate evidence review on GMJ News →Complete clinical article, references and updates on news.gmj.ge. This page is the structured safety summary.
1
Safe
Magnesium L-Threonate
Magnesium L-threonate (Magtein®)
Generally SafeLimitedMajor Minerals
RDA
1,500–2,000 mg
Target
Improvement at 12 weeks
Upper limit
350 mg Mg
Products
1
Dosage by population group — reference
🔗 Best with: Citicoline, Omega-3 DHA, Lion's Mane✅ USP Verified, NSF Contents Certified, Clean Label Project Certified
⚠ For brain/cognitive: MgT. For general Mg: glycinate or citrate [1]
⚠ Only 144 mg elemental Mg per 2,000 mg dose — not for general Mg supplementation [1]
⚠ One positive cognitive RCT — promising but needs replication [2]
ℹ️ Not obtained from food. Not applicable — this is not obtained from food in meaningful amounts; supplementation is the practical route.
🔬 Lab interpreter
Recommended test
Cognitive assessment
Reference range / target
Improvement at 12 weeks
When to test
12 weeks [2].
Only validated outcome from RCT [2].
Full lab monitoring ↓
⚕ For professionals — confirm ranges against your local laboratory.
Clinical verdict
MgT (Magtein) is MIT-designed specifically for brain Mg delivery — the only Mg form with a positive cognitive RCT. Preclinical: 15% brain Mg increase vs 0% for other forms. BUT: only one human trial, expensive, and provides only 144 mg elemental Mg (not for general Mg deficiency). Brain-specific applications only [1] [2].
1 How much do I need?
👤 Adults: Specific dosage data under clinical review
👴 Elderly: Specific dosage data under clinical review
🤰 Pregnancy: See guidance
No data. Low elemental Mg [1].
👦 Pediatric: See guidance
No data [1].
🏃 Athletes: Standard dose
⚖️ Obesity: Standard dose
Fat-soluble compounds may require dose adjustment in obesity.
🩺 Renal: Consult specialist
Dose adjustment may be needed in renal impairment.
🌱 Vegan: Standard dose

How to take

🍽 Timing: Divided BID (morning + evening) [2].
💊 With food: With or without food [1].
🚫 Avoid: As sole Mg supplement (low elemental Mg) [1].
2 Which form?
FormBioavailabilityVeganCost
['Magtein (Mg L-threonate)', 'preferred', 'Patented. 2,000 mg/day (=144 mg elemental Mg). Most data [1].']StandardCheck label
3 Common questions
Is MgT better than glycinate for the brain? ▼
MgT was designed specifically for brain delivery and has the only positive cognitive RCT among Mg forms [1] [2]. Glycinate provides more elemental Mg and is better for general supplementation, sleep, and muscle. For BRAIN-SPECIFIC applications, MgT has the best rationale.
Why is MgT expensive? ▼
Patented (Magtein), complex synthesis, and low elemental Mg per gram (need more product). You're paying for brain delivery, not elemental Mg quantity [1].
Can I take MgT for general Mg deficiency? ▼
Not ideal — only 144 mg elemental Mg per 2,000 mg dose. For general Mg, use glycinate or citrate (more elemental Mg per capsule, cheaper). MgT is specifically for cognitive applications [1].
4 Clinical evidence

Strong

Preclinical: MgT increased brain Mg 15% vs 0% for other forms; enhanced synaptic density and plasticity in aging rats [1]. HIGH

Moderate

Human RCT (n=44, older adults): Magtein improved composite cognitive scores, particularly executive function, at 12 weeks [2]. MODERATE

Insufficient

Alzheimer prevention/treatment [1]. Anxiety/depression (brain Mg theory) [1]. Sleep (limited data) [1]. Comparison to other Mg forms for cognitive outcomes [2]. LOW
5 Safety, toxicity & adverse events

Absolute contraindications

✕ Severe renal failure (GFR <30) — hypermagnesemia risk

Relative

⚠ Myasthenia gravis
⚠ Heart block
⚠ Delivers less elemental magnesium per gram — not ideal for correcting systemic deficiency

🚩 Red flags

● Patient using MgT as SOLE Mg supplement — insufficient elemental Mg [1]
6 Interactions

Supplement synergies

Citicoline + Lion's Mane · 500 mg citicoline + 500–1,000 mg Lion's Mane
Triple nootropic stack: MgT (synaptic Mg) + citicoline (choline/membrane) + Lion's Mane (NGF) [1].
7 Regulatory
United States: Dietary supplement. Magtein: patented [1].
8 US supplement products
1
on-market products containing Magnesium L-Threonate (NIH DSLD)

Brands carrying Magnesium L-Threonate (1)

Click a brand to see its Magnesium L-Threonate products.
Or browse all 1 products in one list →
9 Frequently paired with
Calcium 1 sharedMagnesium 1 shared
Magnesium L-Threonate vs CiticolineMagnesium L-Threonate vs Omega-3 DHA
10 Cite this page
Vancouver: Pkhakadze G. Magnesium L-Threonate — safety profile [Internet]. Tbilisi: PHIG; 2026 [cited 2026 Aug 15]. Available from: https://supplement.ge/ingredients/magnesium-l-threonate/
APA 7th: Pkhakadze, G. (2026). Magnesium L-Threonate — Safety profile. Public Health Institute of Georgia. https://supplement.ge/ingredients/magnesium-l-threonate/
📋 Editorial information
Author: Prof. G. Pkhakadze, MD, MPH, PhD
Affiliation: David Tvildiani Medical University (DTMU)
First published: January 2026
Last reviewed: 2026-05-29
Next review: February 2027
References: 2 cited sources
COI: SupplementIndex receives no funding from supplement manufacturers. All content independently authored by PHIG.
Process: Systematic literature review
📄 License & reuse
Published under Creative Commons Attribution 4.0 International (CC BY 4.0). You may share and adapt for any purpose with attribution.
Pkhakadze G. "Magnesium L-Threonate — Safety Profile." SupplementIndex, PHIG, 2026. https://supplement.ge/ingredients/magnesium-l-threonate/ CC BY 4.0.
GP
Prof. G. Pkhakadze, MD, MPH, PhD
Professor of Public Health · Head of Department, DTMU
Editor-in-Chief, Georgian Medical Journal (ISSN 3088-4322)
Chair, Public Health Institute of Georgia · UEMS Public Health Section
Educational and public health purposes. CC BY 4.0. Consult your healthcare provider before starting any supplement. Corrections: info@accreditation.ge. Publisher: PHIG