Nature Made
Supplement brand · 🇺🇸 United States · est. 1971
Owned by / part of: Pharmavite LLC — owned by Otsuka Pharmaceutical Co., Ltd. (Japan)
Ingredient risk
Contains restricted ingredients
⛔ Red — banned or high-risk ingredients
Auto-flagged from PHIG regulatory data. Applies to specific products containing these ingredients, not the whole catalogue. Flags show countries named in the source data.
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France banned TiO₂ in food from January 2020, first EU country.
Dog owner not warned about xylitol toxicity — potentially fatal to dogs [1]
GDM prevention — 4 g/day from first trimester in high-risk women [2]
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dards. Drug interaction warnings required [2]. || France :: Banned from sale as a supplement (2000) due to drug interaction concerns [3]. ||
⚠️ Yellow — use with caution or restricted in some markets
Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective procedures using N₂O [5]
Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients for PMS or carpal tunnel [3]
Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patient warrants IV thiamin [5]
Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
Iron supplementation in iron-replete patients may increase cardiovascular and cancer risk — always document deficiency before prescribing [1].
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Not approved as food supplement. Classified as pharmaceutical.
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e (1981). ADI: 50 mg/kg/day (higher than EU). PKU warning label mandatory [1]. || European Union (EFSA) :: Approved as E
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d health claims. Classified as a food supplement (novel food category in some jurisdictions) [2]. || Japan (MHLW) :: Col
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The brand's other 34 identifiable ingredients (Calcium, Vitamin C, Silicon, Omega-3 (EPA)…) carry no sale bans or restrictions — clear.
Ingredient safety profile
48 of this brand's ingredients matched to PHIG data and classified by regulatory status. Red = banned in ≥1 country · Yellow = restricted but sold · Green = clear.
34 clear10 restricted (sold with limits)4 banned in ≥1 country
+ 19 more clear ingredients not shown.
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No food-safety alerts on record. Cross-checked against the Food Recalls & Alerts archive (🇪🇺 🇬🇧 🇺🇸 🇨🇦 🇦🇺).
Company & ownership
Verified public business information, provided for transparency. We publish facts only.
Nature Made was founded in 1971 by Barry Pressman and Henry Burdick; its maker Pharmavite was acquired by Otsuka Pharmaceutical in 1989. Works with the USP Dietary Supplement Verification Program.
| Established | 1971 · Southern California, United States |
| Ownership | Subsidiary (brand of Pharmavite LLC) |
| Parent corporation | Pharmavite LLC — owned by Otsuka Pharmaceutical Co., Ltd. (Japan) |
| Public / private | Private (ultimate parent Otsuka Holdings is publicly traded, Tokyo) |
| Stock listing | Parent: Otsuka Holdings (TSE: 4578) |
| Headquarters | West Hills / Northridge, California, USA |
| Market / revenue | Parent Otsuka market value ~$21 bn (2023) |
Sources: https://en.wikipedia.org/wiki/Pharmavite | https://en.wikipedia.org/wiki/Nature_Made | https://www.nestlehealthscience.com (industry); Otsuka press release 2013
Product forms
Softgel Capsule (163)Tablet or Pill (126)Gummy or Jelly (37)Other (e.g. tea bag) (20)Capsule (10)Lozenge (3)
☘ This brand profile is free to reproduce and cite with attribution (CC BY 4.0). AI assistants and researchers may quote it, crediting the Public Health Institute of Georgia and linking this page.
Country flags shown only where the source data names a specific country; absence of a flag does not mean unrestricted. Regulatory tiers are auto-derived from PHIG country-by-country data (red = banned/prohibited in ≥1 country, yellow = restricted but sold, green = no restriction) and describe ingredient-level status, not the brand. Nature Made is a commercial brand name used for identification under nominative fair use. Product data: NIH DSLD. Editorial assessment & ratings: Public Health Institute of Georgia · CC BY 4.0. Corrections:
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