1 Product identity
Ingredient risk
Contains restricted ingredients
Prena1 With Quatrefolic
BrandBocaGreenMD→Other Combinations Softgel Capsule 31 ingredients 1 banned 6 caution DSLD #43222Net contents: 30 Softgel(s)
Target: Pregnant and Lactating
DSLD entry: 2015-03-25
2 Ingredients (31)
IngredientGroupSafety
Quatrefolic(R)5-methyltetrahydrofolate glucosamine—
Docosahexaenoic AcidDHA (Docosahexaenoic Acid)—
Gelatin Capsulecapsule—
high Oleic Sunflower OilSunflower Oil—
BeeswaxBeeswax—
Glycerol MonostearateGlycerol Monostearate—
Soybean Lecithinlecithin—
purified WaterWater—
Sunflower Lecithinlecithin—
TocopherolsVitamin E (mixed tocopherols)—
D&C Red #33Color—
FD&C Red #40Color—
FD&C Blue #1Color—
Orange Essential OilOrange (unspecified)—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ Contains an ingredient banned in ≥1 country
Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Iron — Iron supplementation in iron-replete patients may increase cardiovascular and cancer risk — always document deficiency before prescribing [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
3 Safety cross-reference
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Thiamin — Use with Caution
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Biotin — Generally Safe
⚠ Interferes with troponin and thyroid lab assays
Pantothenic Acid — Limited Evidence
⚠ Diarrhea at very high doses
Iron — Use with Caution
⚠ GI upset, constipation
⚠ Fatal toxicity in children
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Titanium Dioxide — Banned in ≥1 country
⚠ EFSA: can no longer be considered safe as food additive (2021)
⚠ Genotoxicity concern (nanoparticles)
Rosemary Extract — Limited Evidence
⚠ Seizure risk at very high doses
⚠ May affect blood glucose
4 Label claims
• Nutrient
• All Other
5 Data source
DSLD ID43222
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2015-03-25
6 More from BocaGreenMD
View BocaGreenMD Safety Scorecard → 4 products
DHAMultivitamin/MultimineralPrena1 Chew With Quatrefolic7 Cite this page
Vancouver
Pkhakadze G. Prena1 With Quatrefolic — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jun 25]. Available from: https://supplement.ge/products/prena1-with-quatrefolic-43222/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG