1 Product identity
Ingredient risk
4 ingredients to use with caution
Prena1 Chew With Quatrefolic
BrandBocaGreenMD→Vitamin Tablet or Pill 12 ingredients 4 caution DSLD #43211Net contents: 30 Chewable Tablet(s)
Target: Pregnant and Lactating
DSLD entry: 2015-03-25
2 Ingredients (12)
IngredientGroupSafety
Quatrefolic(R)5-methyltetrahydrofolate glucosamine—
MannitolMannitol—
natural Masking FlavorFlavor—
natural Vanilla flavorVanilla—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
3 Safety cross-reference
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Vitamin B6 — Use with Caution
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Silicon — Generally Safe
⚠ Very low toxicity
4 Label claims
• All Other
5 Data source
DSLD ID43211
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2015-03-25
6 More from BocaGreenMD
View BocaGreenMD Safety Scorecard → 4 products
DHAMultivitamin/MultimineralPrena1 With Quatrefolic7 Cite this page
Vancouver
Pkhakadze G. Prena1 Chew With Quatrefolic — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jun 25]. Available from: https://supplement.ge/products/prena1-chew-with-quatrefolic-43211/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG