1 Product identity

Ingredient risk

4 ingredients to use with caution

EstroFactors

Name: EstroFactors
Brand: Metagenics

BrandMetagenics→Other Combinations Tablet or Pill 22 ingredients 4 caution DSLD #26822

Net contents: 180 Tablet(s)

Target: Adults and Children 4 years and above

DSLD entry: 2013-10-25

2 Ingredients (22)

IngredientGroupSafety

Vitamin AVitamin A (unspecified)—

Vitamin DVitamin DUse with Caution

Vitamin EVitamin EConditionally Safe

Vitamin KVitamin KConditionally Safe

Vitamin B6Vitamin B6Use with Caution

FolateVitamin B9 (Folate)—

Vitamin B12Vitamin B12Use with Caution

Isoflavonesisoflavone (unspecified)—

red clover (Trifolium pratense) flowering top extractRed CloverConditionally Safe

kudzu root extractKudzu —

Turmeric Rhizome ExtractTurmericConditionally Safe

Rosemary Leaf ExtractRosemary —

ResveratrolResveratrolConditionally Safe

TrimethylglycineBetaine—

ChrysinChrysin—

Stearic AcidStearic Acid—

Microcrystalline CelluloseCellulose—

Calcium SilicateCalcium Silicate—

Croscarmellose SodiumCroscarmellose Sodium—

SilicaSiliconGenerally Safe

Magnesium StearateMagnesiumUse with Caution

CoatingCoating—

Ingredient amounts require the full DSLD label. View full label at NIH DSLD →

⚠️ Use with caution — restricted in some markets

Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]

Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…

Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…

Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].

3 Safety cross-reference

Vitamin A — Limited Evidence

⚠ Teratogenic at high doses

⚠ Hepatotoxic with chronic excess

Vitamin D — Use with Caution

⚠ Hypercalcemia at >10,000 IU/day

⚠ Vascular calcification risk

Vitamin E — Conditionally Safe

⚠ Increased bleeding risk

⚠ All-cause mortality at >400 IU/day

Vitamin K — Conditionally Safe

⚠ Critical interaction with warfarin

Vitamin B6 — Use with Caution

Folate — Limited Evidence

⚠ May mask B12 deficiency

⚠ Colorectal cancer risk debated

Vitamin B12 — Use with Caution

Red Clover — Conditionally Safe

⚠ Estrogenic (isoflavones)

⚠ May increase bleeding risk

Resveratrol — Conditionally Safe

⚠ Estrogenic activity

⚠ CYP enzyme inhibition

Glycine — Limited Evidence

⚠ Well tolerated

Calcium — Limited Evidence

⚠ Cardiovascular risk debated >1,000 mg/day

⚠ Kidney stones

Sodium — Limited Evidence

⚠ Hypertension

⚠ Fluid retention

Silicon — Generally Safe

⚠ Very low toxicity

Magnesium — Use with Caution

⚠ Diarrhea (especially oxide)

⚠ Accumulates in renal impairment

4 Label claims

• Nutrient

• All Other

• Structure/Function

5 Data source

DSLD ID26822

Full labelView at NIH DSLD →

SourceOffice of Dietary Supplements, NIH

Market statusOn market

Entry date2013-10-25

6 More from Metagenics

View Metagenics Safety Scorecard → 118 products

ActiFolate AdvaClear Arginine Plus Axis Endo Mango Flavor Azeo-Pangen Azeo-Pangen

7 Cite this page

Vancouver

Pkhakadze G. EstroFactors — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Aug 24]. Available from: https://supplement.ge/products/estrofactors-26822/

CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.

Analyzed by SupplementIndex

PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD

Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG