1 Product identity
Ingredient risk
Contains restricted ingredients
Double-Strength SAMe 400
BrandDoctor's Best→Non-Nutrient/Non-Botanical Tablet or Pill 15 ingredients 1 banned 2 caution DSLD #25576Net contents: 60 Enteric Coated Tablet(s)
Target: Adults and Children 4 years and above
DSLD entry: 2013-09-25
2 Ingredients (15)
IngredientGroupSafety
Cellulose GelCellulose Gel—
Methacrylic Acid CopolymerPolyacrylate—
Compritol 888ATOEmulsifying agent—
Triethyl Citratetriethylcitrate—
MannitolMannitol—
Glycerol PalmitostearateGlyceryl palmitostearate—
Medium Chain TriglyceridesMedium chain triglycerides (MCT)—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ Contains an ingredient banned in ≥1 country
Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.
⚠️ Use with caution — restricted in some markets
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Iron — Iron supplementation in iron-replete patients may increase cardiovascular and cancer risk — always document deficiency before prescribing [1].
3 Safety cross-reference
SAMe — Conditionally Safe
⚠ Mania in bipolar
⚠ Serotonin syndrome with SSRIs
Magnesium — Use with Caution
Titanium Dioxide — Banned in ≥1 country
⚠ EFSA: can no longer be considered safe as food additive (2021)
⚠ Genotoxicity concern (nanoparticles)
Silicon — Generally Safe
⚠ Very low toxicity
Sodium — Limited Evidence
⚠ Hypertension
⚠ Fluid retention
Iron — Use with Caution
⚠ GI upset, constipation
⚠ Fatal toxicity in children
4 Label claims
• All Other
• Structure/Function
5 Data source
DSLD ID25576
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2013-09-25
6 More from Doctor's Best
View Doctor's Best Safety Scorecard → 152 products
5-HTP 100 mg5-HTP Enhanced with Vitamins B6 and CAcetyl-L-CarnitineAcetyl-L-Carnitine With Biosint Carnitines 500 mgAlpha-Lipoic Acid 600Ashwagandha With Sensoril 125 mg7 Cite this page
Vancouver
Pkhakadze G. Double-Strength SAMe 400 — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Oct 21]. Available from: https://supplement.ge/products/double-strength-same-400-25576/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG