1 Product identity

Ingredient risk

Contains restricted ingredients

Double-Strength SAMe 400

Name: Double-Strength SAMe 400
Brand: Doctor's Best

BrandDoctor's Best→Non-Nutrient/Non-Botanical Tablet or Pill 15 ingredients 1 banned 2 caution DSLD #25576

Net contents: 60 Enteric Coated Tablet(s)

Target: Adults and Children 4 years and above

DSLD entry: 2013-09-25

2 Ingredients (15)

IngredientGroupSafety

S-Adenosyl MethionineSAMeConditionally Safe

from 800 mg of SAM-e tosylate disulfateSAMeConditionally Safe

Cellulose GelCellulose Gel—

Methacrylic Acid CopolymerPolyacrylate—

Compritol 888ATOEmulsifying agent—

TalcMagnesium SilicateUse with Caution

Triethyl Citratetriethylcitrate—

Titanium DioxideTitanium DioxideBanned in ≥1 country

Magnesium StearateMagnesium stearateUse with Caution

MannitolMannitol—

Glycerol PalmitostearateGlyceryl palmitostearate—

SilicaSiliconGenerally Safe

Medium Chain TriglyceridesMedium chain triglycerides (MCT)—

Sodium Starch GlycolateSodium Starch Glycolate—

Iron OxideIronUse with Caution

Ingredient amounts require the full DSLD label. View full label at NIH DSLD →

⛔ Contains an ingredient banned in ≥1 country

Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.

⚠️ Use with caution — restricted in some markets

Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].

Iron — Iron supplementation in iron-replete patients may increase cardiovascular and cancer risk — always document deficiency before prescribing [1].

3 Safety cross-reference

SAMe — Conditionally Safe

⚠ Mania in bipolar

⚠ Serotonin syndrome with SSRIs

Magnesium — Use with Caution

Titanium Dioxide — Banned in ≥1 country

⚠ EFSA: can no longer be considered safe as food additive (2021)

⚠ Genotoxicity concern (nanoparticles)

Silicon — Generally Safe

⚠ Very low toxicity

Sodium — Limited Evidence

⚠ Hypertension

⚠ Fluid retention

Iron — Use with Caution

⚠ GI upset, constipation

⚠ Fatal toxicity in children

4 Label claims

• All Other

• Structure/Function

5 Data source

DSLD ID25576

Full labelView at NIH DSLD →

SourceOffice of Dietary Supplements, NIH

Market statusOn market

Entry date2013-09-25

6 More from Doctor's Best

View Doctor's Best Safety Scorecard → 152 products

5-HTP 100 mg 5-HTP Enhanced with Vitamins B6 and C Acetyl-L-Carnitine Acetyl-L-Carnitine With Biosint Carnitines 500 mg Alpha-Lipoic Acid 600 Ashwagandha With Sensoril 125 mg

7 Cite this page

Vancouver

Pkhakadze G. Double-Strength SAMe 400 — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jul 30]. Available from: https://supplement.ge/products/double-strength-same-400-25576/

CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.

Analyzed by SupplementIndex

PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD

Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG