1 Product identity
Ingredient risk
Contains restricted ingredients
Centrum Silver Adults 50+
BrandCentrum→Other Combinations Tablet or Pill 76 ingredients 1 banned 6 caution DSLD #277821Net contents: 325 Tablet(s)
Target: Adults and Children 4 years and above
DSLD entry: 2022-10-24
2 Ingredients (76)
IngredientGroupSafety
NickelNickel—
LycopeneLycopene—
Microcrystalline CelluloseCellulose—
Modified Corn Starchmodified Starch—
Corn StarchStarch—
MaltodextrinMaltodextrin—
Butylated HydroxytolueneButylated hydroxytoluene—
Blue 2 LakeColor—
CrospovidoneCrospovidone—
GelatinGelatin—
Palm Oil, HydrogenatedPalm Oil—
HypromelloseHypromellose—
Medium Chain TriglycerideMedium chain triglycerides (MCT)—
Nickelous SulfateNickel sulfate—
PolydextrosePolydextrose—
pregelatinized Corn StarchPregelatinized starch—
Red 40 LakeColor—
Yellow 6 LakeColor—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ Contains an ingredient banned in ≥1 country
Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
3 Safety cross-reference
Vitamin A — Conditionally Safe
⚠ Teratogenic at high doses
⚠ Hepatotoxic with chronic excess
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Vitamin K — Conditionally Safe
⚠ Critical interaction with warfarin
Thiamin — Use with Caution
⚠ Very low toxicity
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Biotin — Generally Safe
⚠ Interferes with troponin and thyroid lab assays
Pantothenic Acid — Limited Evidence
⚠ Diarrhea at very high doses
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Phosphorus — Generally Safe
⚠ Excess impairs calcium absorption
Iodine — Conditionally Safe
⚠ Thyroid dysfunction at excess
⚠ Kelp: variable content
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Selenium — Conditionally Safe
⚠ Selenosis >400 mcg
⚠ Diabetes risk at high doses
Copper — Conditionally Safe
⚠ Hepatotoxicity at high doses
Manganese — Conditionally Safe
⚠ Neurotoxicity with chronic excess
Chromium — Conditionally Safe
⚠ Hypoglycemia with diabetes meds
⚠ Rare renal/hepatic toxicity
Molybdenum — Generally Safe
⚠ Very low toxicity
Chloride — Generally Safe
⚠ Co-ingested with sodium
Potassium — Conditionally Safe
⚠ Hyperkalemia risk
⚠ Dangerous with ACE inhibitors
Silicon — Generally Safe
⚠ Very low toxicity
Vanadium — Limited Evidence
⚠ GI toxicity: nausea, vomiting, diarrhea
⚠ Green tongue
Lutein — Generally Safe
⚠ Harmless skin yellowing at very high doses
Sodium — Conditionally Safe
⚠ Hypertension
⚠ Fluid retention
Titanium Dioxide — Banned in ≥1 country
⚠ EFSA: can no longer be considered safe as food additive (2021)
⚠ Genotoxicity concern (nanoparticles)
4 Label claims
• Nutrient
• All Other
• Structure/Function
5 Data source
DSLD ID277821
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2022-10-24
6 More from Centrum
View Centrum Safety Scorecard → 31 products
Centrum Adults Under 50Centrum Adults Under 50Centrum Adults Under 50Centrum Flavor Burst Mixed FruitCentrum Flavor Burst Mixed FruitCentrum Flavor Burst Wild Grape7 Cite this page
Vancouver
Pkhakadze G. Centrum Silver Adults 50+ — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jul 29]. Available from: https://supplement.ge/products/centrum-silver-adults-50-277821/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG