✓ No active regulatory warningsFDA MedWatch, EMA EudraVigilance, WHO VigiBase, WADA Prohibited List · 2026-05-29
Updated: 2026-05-29 · v2.0 · Prof. G. Pkhakadze, MD, MPH, PhDCiteEditorial
📰Read the full Olive Leaf Extract evidence review on GMJ News →Complete clinical article, references and updates on news.gmj.ge. This page is the structured safety summary.
1
Safe
Olive Leaf Extract
Olea europaea
Generally SafeLimitedBotanicals
RDA
Typical 500–1,000 mg
Target
<130/80
Upper limit
No UL
Products
11
Dosage by population group — reference
🔗 Best with: Garlic Extract, CoQ10, Omega-3 (EPA)✅ USP Verified, ConsumerLab Approved, Clean Label Project Certified
⚠ One RCT comparable to captopril — but single trial needs replication [2]
⚠ Additive BP lowering with antihypertensives [2]
ℹ️ Not obtained from food. Not applicable — this is not obtained from food in meaningful amounts; supplementation is the practical route.
🔬 Lab interpreter
Recommended test
Blood pressure
Reference range / target
<130/80
When to test
Weekly initially [2].
~5 mmHg SBP reduction expected [2].
Full lab monitoring ↓
⚕ For professionals — confirm ranges against your local laboratory.
Clinical verdict
Olive leaf extract (oleuropein/hydroxytyrosol) has one impressive RCT: comparable to captopril for mild hypertension. Potent polyphenolic antioxidant. EFSA health claim for olive oil polyphenols exists. Single trial — needs replication before replacing BP medication [1] [2].
1 How much do I need?
👤 Adults: Specific dosage data under clinical review
👴 Elderly: Specific dosage data under clinical review
🤰 Pregnancy: See guidance
Limited data. Avoid [1].
👦 Pediatric: See guidance
No data [1].
🏃 Athletes: Standard dose
⚖️ Obesity: Standard dose
Fat-soluble compounds may require dose adjustment in obesity.
🩺 Renal: Consult specialist
Dose adjustment may be needed in renal impairment.
🌱 Vegan: Standard dose

How to take

🍽 Timing: BID with meals [2].
💊 With food: With food [1].
🚫 Avoid: Concurrent antihypertensives without monitoring [2].
2 Which form?
FormBioavailabilityVeganCost
['Standardized extract (15–20% oleuropein)', 'preferred', '500 mg BID. Most clinical data [2].']StandardCheck label
3 Common questions
Is olive leaf comparable to blood pressure medication? ▼
One small RCT found 500 mg BID comparable to captopril 12.5 mg BID for mild hypertension. This is a single trial — not enough to replace medication, but promising as a natural option for prehypertension or mild hypertension [2].
4 Clinical evidence

Strong

Oleuropein and hydroxytyrosol are potent antioxidants — well-characterized [1]. HIGH

Moderate

Blood pressure: one RCT found olive leaf 500 mg BID comparable to captopril 12.5 mg BID for stage 1 hypertension (SBP ~5 mmHg reduction) [2]. Lipids: modest LDL reduction in some trials [2]. Antimicrobial: in vitro activity against bacteria, viruses, fungi [1]. MODERATE

Insufficient

Diabetes [1]. Cancer [1]. Immune enhancement [1]. Weight loss [1]. LOW
5 Safety, toxicity & adverse events

Relative

⚠ Antihypertensives — additive blood-pressure lowering
⚠ Antidiabetics — additive glucose lowering
⚠ Anticoagulants — possible additive effect
⚠ Pregnancy and lactation — limited data

🚩 Red flags

● Patient replacing BP medication with olive leaf based on one trial — premature [2]
6 Interactions

Drug interactions

Antihypertensives Moderate
Mechanism: Additive BP lowering. [2]
Effect: Hypotension risk. [2]
Action: Monitor BP [2].

Supplement synergies

CoQ10 · 100–200 mg CoQ10
Complementary cardiovascular effects [1].
7 Regulatory
European Union: EFSA: authorized health claims for olive oil polyphenols (hydroxytyrosol) for LDL oxidation protection [1].
United States: Dietary supplement [1].
8 US supplement products
11
on-market products containing Olive Leaf Extract (NIH DSLD)

Brands carrying Olive Leaf Extract (3)

Click a brand to see its Olive Leaf Extract products.
Or browse all 11 products in one list →
9 Frequently paired with
Vitamin C 4 sharedZinc 3 sharedSelenium 3 sharedVitamin E 2 sharedEchinacea 2 shared
Olive Leaf Extract vs Garlic ExtractOlive Leaf Extract vs CoQ10
10 Cite this page
Vancouver: Pkhakadze G. Olive Leaf Extract — safety profile [Internet]. Tbilisi: PHIG; 2026 [cited 2026 Aug 15]. Available from: https://supplement.ge/ingredients/olive-leaf-extract/
APA 7th: Pkhakadze, G. (2026). Olive Leaf Extract — Safety profile. Public Health Institute of Georgia. https://supplement.ge/ingredients/olive-leaf-extract/
📋 Editorial information
Author: Prof. G. Pkhakadze, MD, MPH, PhD
Affiliation: David Tvildiani Medical University (DTMU)
First published: January 2026
Last reviewed: 2026-05-29
Next review: February 2027
References: 2 cited sources
COI: SupplementIndex receives no funding from supplement manufacturers. All content independently authored by PHIG.
Process: Systematic literature review
📄 License & reuse
Published under Creative Commons Attribution 4.0 International (CC BY 4.0). You may share and adapt for any purpose with attribution.
Pkhakadze G. "Olive Leaf Extract — Safety Profile." SupplementIndex, PHIG, 2026. https://supplement.ge/ingredients/olive-leaf-extract/ CC BY 4.0.
GP
Prof. G. Pkhakadze, MD, MPH, PhD
Professor of Public Health · Head of Department, DTMU
Editor-in-Chief, Georgian Medical Journal (ISSN 3088-4322)
Chair, Public Health Institute of Georgia · UEMS Public Health Section
Educational and public health purposes. CC BY 4.0. Consult your healthcare provider before starting any supplement. Corrections: info@accreditation.ge. Publisher: PHIG