1 Product identity
Ingredient risk
Contains restricted ingredients
SAM-e
BrandDouglas Laboratories→Non-Nutrient/Non-Botanical Tablet or Pill 14 ingredients 1 banned 2 caution DSLD #57532Net contents: 30 Enteric Coated Tablet(s)
Target: Adults and Children 4 years and above
DSLD entry: 2016-03-24
2 Ingredients (14)
IngredientGroupSafety
Microcrystalline CelluloseCellulose—
MannitolMannitol—
Glycerol BehenateGlyceride—
Methacrylic Acid CopolymerPolyacrylate—
Glycerol PalmitostearateGlyceryl palmitostearate—
Medium Chain TriglyceridesMedium chain triglycerides (MCT)—
Triethyl Citratetriethylcitrate—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ Contains an ingredient banned in ≥1 country
Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.
⚠️ Use with caution — restricted in some markets
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Iron — Iron supplementation in iron-replete patients may increase cardiovascular and cancer risk — always document deficiency before prescribing [1].
3 Safety cross-reference
SAMe — Conditionally Safe
⚠ Mania in bipolar
⚠ Serotonin syndrome with SSRIs
Sodium — Limited Evidence
⚠ Hypertension
⚠ Fluid retention
Magnesium — Use with Caution
Titanium Dioxide — Banned in ≥1 country
⚠ EFSA: can no longer be considered safe as food additive (2021)
⚠ Genotoxicity concern (nanoparticles)
Silicon — Generally Safe
⚠ Very low toxicity
Iron — Use with Caution
⚠ GI upset, constipation
⚠ Fatal toxicity in children
4 Label claims
• All Other
5 Data source
DSLD ID57532
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2016-03-24
6 More from Douglas Laboratories
View Douglas Laboratories Safety Scorecard → 788 products
A-Potene 10A-Potene 25A-Retic Natural Herbal FormulaA-Retic Natural Herbal FormulaA.R. FormulaA.R.M.D. Eye Support7 Cite this page
Vancouver
Pkhakadze G. SAM-e — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Oct 21]. Available from: https://supplement.ge/products/sam-e-57532/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG