1 Product identity

Estro Support

Name: Estro Support
Brand: 21st Century

Brand21st Century→Botanical with Nutrients Tablet or Pill 25 ingredients DSLD #43816

Net contents: 60 Tablet(s)

Target: Adults and Children 4 years and above

DSLD entry: 2015-03-25

2 Ingredients (25)

IngredientGroupSafety

Vitamin EVitamin EConditionally Safe

ThiamineThiaminGenerally Safe

RiboflavinRiboflavinGenerally Safe

NiacinNiacinConditionally Safe

Vitamin B6Vitamin B6—

Folic AcidFolateConditionally Safe

Vitamin B12Vitamin B12—

CalciumCalciumConditionally Safe

SeleniumSeleniumConditionally Safe

BlendBlend (Herb/Botanical)—

Dateseed extractJujube seeds—

Magnolia bark extractMagnolia —

purified Isoflavonesisoflavone (unspecified)—

Black Cohosh extractBlack CohoshLimited Evidence

BoronBoronConditionally Safe

CelluloseCellulose—

Croscarmellose SodiumCroscarmellose SodiumConditionally Safe

MaltodextrinMaltodextrin—

Silicon DioxideSiliconGenerally Safe

Stearic AcidStearic Acid—

PolydextrosePolydextrose—

Magnesium StearateMagnesium stearateGenerally Safe

Titanium DioxideTitanium DioxideLimited Evidence

Artificial colorsColor—

PEGPolyethylene glycol—

Ingredient amounts require the full DSLD label. View full label at NIH DSLD →

3 Safety cross-reference

Vitamin E — Conditionally Safe

⚠ Increased bleeding risk

⚠ All-cause mortality at >400 IU/day

Thiamine — Generally Safe

⚠ Very low toxicity

Riboflavin — Generally Safe

⚠ Harmless yellow urine

Niacin — Conditionally Safe

⚠ Flushing at >50 mg

⚠ Hepatotoxicity at high doses

Folate — Conditionally Safe

⚠ May mask B12 deficiency

⚠ Colorectal cancer risk debated

Calcium — Conditionally Safe

⚠ Cardiovascular risk debated >1,000 mg/day

⚠ Kidney stones

Selenium — Conditionally Safe

⚠ Selenosis >400 mcg

⚠ Diabetes risk at high doses

Black Cohosh — Limited Evidence

⚠ HEPATOTOXICITY (rare but serious)

⚠ Limit to 6 months

Boron — Conditionally Safe

⚠ Reproductive toxicity in animals

Sodium — Conditionally Safe

⚠ Hypertension

⚠ Fluid retention

Silicon — Generally Safe

⚠ Very low toxicity

Magnesium — Generally Safe

⚠ Diarrhea (especially oxide)

⚠ Accumulates in renal impairment

Titanium Dioxide — Limited Evidence

⚠ EFSA: can no longer be considered safe as food additive (2021)

⚠ Genotoxicity concern (nanoparticles)

4 Label claims

• All Other

• Structure/Function

5 Data source

DSLD ID43816

Full labelView at NIH DSLD →

SourceOffice of Dietary Supplements, NIH

Market statusOn market

Entry date2015-03-25

6 More from 21st Century

View 21st Century Safety Scorecard → 153 products

600 + D3 plus Minerals 600 Calcium Supplement 600+D3 600+D3 600+D3 Acai 1000 mg

7 Cite this page

Vancouver

Pkhakadze G. Estro Support — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jun 02]. Available from: https://supplement.ge/products/estro-support-43816/

CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.

Analyzed by SupplementIndex

PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD

Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG