1 Product identity
Ingredient risk
Contains restricted ingredients
Estro Support
Brand21st Century→Botanical with Nutrients Tablet or Pill 25 ingredients 1 banned 1 high-risk 4 caution DSLD #43816Net contents: 60 Tablet(s)
Target: Adults and Children 4 years and above
DSLD entry: 2015-03-25
2 Ingredients (25)
IngredientGroupSafety
BlendBlend (Herb/Botanical)—
Dateseed extractJujube seeds—
Magnolia bark extractMagnolia —
purified Isoflavonesisoflavone (unspecified)—
CelluloseCellulose—
MaltodextrinMaltodextrin—
Stearic AcidStearic Acid—
PolydextrosePolydextrose—
Artificial colorsColor—
PEGPolyethylene glycol—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ High-risk ingredient — documented serious harm
Black Cohosh 🇺🇸 🇦🇺 🇪🇺 — Hepatotoxicity cases including liver failure — limit 6 months [1]
⛔ Contains an ingredient banned in ≥1 country
Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.
⚠️ Use with caution — restricted in some markets
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
3 Safety cross-reference
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Thiamin — Use with Caution
⚠ Very low toxicity
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Selenium — Conditionally Safe
⚠ Selenosis >400 mcg
⚠ Diabetes risk at high doses
Black Cohosh — High risk
⚠ HEPATOTOXICITY (rare but serious)
⚠ Limit to 6 months
Boron — Conditionally Safe
⚠ Reproductive toxicity in animals
Sodium — Limited Evidence
⚠ Hypertension
⚠ Fluid retention
Silicon — Generally Safe
⚠ Very low toxicity
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Titanium Dioxide — Banned in ≥1 country
⚠ EFSA: can no longer be considered safe as food additive (2021)
⚠ Genotoxicity concern (nanoparticles)
4 Label claims
• All Other
• Structure/Function
5 Data source
DSLD ID43816
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2015-03-25
6 More from 21st Century
View 21st Century Safety Scorecard → 179 products
600 + D3 plus Minerals600 Calcium Supplement600+D3600+D3600+D3Acai 1000 mg7 Cite this page
Vancouver
Pkhakadze G. Estro Support — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jul 10]. Available from: https://supplement.ge/products/estro-support-43816/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG