1 Product identity
Ingredient risk
Contains restricted ingredients
Enhanced Sleep Formula
BrandGNC Preventive Nutrition→Other Combinations Capsule 24 ingredients 2 banned 4 caution DSLD #27312Net contents: 60 Capsule(s)
Target: Adults and Children 4 years and above
DSLD entry: 2013-11-25
2 Ingredients (24)
IngredientGroupSafety
Folic AcidVitamin B9 (folic acid) —
Calming & Relaxation ComplexBlend (Combination)—
Lemon Balm Extractlemon balm—
Sleep Inducing BlendBlend (Combination)—
Antioxidant Replenishment SystemBlend—
GelatinGelatin—
CelluloseCellulose—
FD&C Blue #1Color—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ Contains an ingredient banned in ≥1 country
GABA 🇺🇸 🇯🇵 — ates (FDA) :: Dietary supplement. Picamilon (GABA + niacin) banned as supplement (2015) [1]. || Japan :: GABA is a popular functional food i
Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.
⚠️ Use with caution — restricted in some markets
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
Melatonin 🇯🇵 🇪🇺 🇦🇺 🇩🇪 🇬🇧 — Not approved as food supplement. Classified as pharmaceutical.
3 Safety cross-reference
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin B6 — Use with Caution
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
L-Theanine — Limited Evidence
⚠ May enhance sedatives
Valerian — Limited Evidence
⚠ Drowsiness
⚠ Additive with sedatives/alcohol
Passionflower — Generally Safe
⚠ Drowsiness
⚠ Uterine stimulant
GABA — Banned in ≥1 country
⚠ Drowsiness
⚠ May enhance sedatives
Melatonin — Use with Caution
⚠ Daytime drowsiness
⚠ May worsen depression
Alpha-Lipoic Acid — Conditionally Safe
⚠ May lower blood glucose
⚠ May lower thyroid hormones
Glutathione — Generally Safe
⚠ Limited oral bioavailability data
⚠ May affect zinc levels
Resveratrol — Conditionally Safe
⚠ Estrogenic activity
⚠ CYP enzyme inhibition
L-Arginine — Limited Evidence
⚠ Hypotension
⚠ May worsen herpes outbreaks
Titanium Dioxide — Banned in ≥1 country
⚠ EFSA: can no longer be considered safe as food additive (2021)
⚠ Genotoxicity concern (nanoparticles)
4 Label claims
• All Other
• Structure/Function
5 Data source
DSLD ID27312
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2013-11-25
6 More from GNC Preventive Nutrition
View GNC Preventive Nutrition Safety Scorecard → 26 products
Astaxanthin 4 mgBlood Circulation - PM PacketBone & Joint Health FormulaBone & Joint Health FormulaCardioAidCleansing Fiber Sachet7 Cite this page
Vancouver
Pkhakadze G. Enhanced Sleep Formula — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Oct 17]. Available from: https://supplement.ge/products/enhanced-sleep-formula-27312/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG