1 Product identity

Ingredient risk

2 ingredients to use with caution

Calorie Restriction Mimetics

Name: Calorie Restriction Mimetics
Brand: Natural Clinician

BrandNatural Clinician→Other Combinations Capsule 14 ingredients 2 caution DSLD #32874

Net contents: 60 Vegetable Capsule(s)

Target: Adults and Children 4 years and above

DSLD entry: 2014-05-23

2 Ingredients (14)

IngredientGroupSafety

A Proprietary BlendProprietary Blend—

ResveratrolResveratrolConditionally Safe

L-CarnosineCarnosine—

Gymnema sylvestreGymnemaConditionally Safe

Alpha Lipoic AcidAlpha Lipoic Acid—

cinnamonCinnamonUse with Caution

N-Acetyl-L-CarnitineAcetyl L-Carnitine—

Grape seed extractGrape —

ellagic acidEllagic Acid—

Green Tea extractGreen Tea—

pinemaritime Pine—

avocadoAvocado—

Vegetable StearateMagnesium stearateUse with Caution

FiberFiber (unspecified)—

Ingredient amounts require the full DSLD label. View full label at NIH DSLD →

⚠️ Use with caution — restricted in some markets

Cinnamon 🇪🇺 — Coumarin TDI 0.1 mg/kg BW/day. Cassia type exceeds limits at typical supplement doses.

Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].

3 Safety cross-reference

Resveratrol — Conditionally Safe

⚠ Estrogenic activity

⚠ CYP enzyme inhibition

Gymnema — Conditionally Safe

⚠ Hypoglycemia with diabetes meds

⚠ Temporarily suppresses sweet taste

Cinnamon — Use with Caution

⚠ Cassia: high coumarin (hepatotoxic)

⚠ May lower glucose

L-Carnitine — Limited Evidence

⚠ Fishy body odor

⚠ TMAO concern

Grape Seed Extract — Limited Evidence

⚠ Antiplatelet effect

⚠ May interact with anticoagulants

Green Tea Extract — Limited Evidence

⚠ HEPATOTOXICITY >800 mg EGCG

⚠ Iron absorption inhibition

Magnesium — Use with Caution

4 Label claims

• All Other

• Structure/Function

5 Data source

DSLD ID32874

Full labelView at NIH DSLD →

SourceOffice of Dietary Supplements, NIH

Market statusOn market

Entry date2014-05-23

6 More from Natural Clinician

View Natural Clinician Safety Scorecard → 28 products

Clinical Advanced Joint Care Clinical Advantra Z Clinical Allergy Clinical Antiangiogenesis Clinical Augmented Silver Colloid Clinical Chelation Companion

7 Cite this page

Vancouver

Pkhakadze G. Calorie Restriction Mimetics — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Aug 26]. Available from: https://supplement.ge/products/calorie-restriction-mimetics-32874/

CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.

Analyzed by SupplementIndex

PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD

Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG