1 Product identity
Ingredient risk
Contains restricted ingredients
Calcium 500+D3
Brand21st Century→Single Vitamin and Mineral Tablet or Pill 11 ingredients 1 banned 2 caution DSLD #43589Net contents: 200 Tablet(s)
Target: Adults and Children 4 years and above
DSLD entry: 2015-03-25
2 Ingredients (11)
IngredientGroupSafety
CelluloseCellulose—
Polyvinyl AlcoholPolyvinyl alcohol—
Stearic AcidStearic Acid—
PEGPolyethylene glycol—
Artificial ColorsColor—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ Contains an ingredient banned in ≥1 country
Titanium Dioxide 🇫🇷 🇪🇺 — France banned TiO₂ in food from January 2020, first EU country.
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
3 Safety cross-reference
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Sodium — Limited Evidence
⚠ Hypertension
⚠ Fluid retention
Titanium Dioxide — Banned in ≥1 country
⚠ EFSA: can no longer be considered safe as food additive (2021)
⚠ Genotoxicity concern (nanoparticles)
Magnesium — Use with Caution
4 Label claims
• Nutrient
• All Other
• Approved Health
• Structure/Function
5 Data source
DSLD ID43589
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2015-03-25
6 More from 21st Century
View 21st Century Safety Scorecard → 179 products
600 + D3 plus Minerals600 Calcium Supplement600+D3600+D3600+D3Acai 1000 mg7 Cite this page
Vancouver
Pkhakadze G. Calcium 500+D3 — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jun 24]. Available from: https://supplement.ge/products/calcium-500d3-43589/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG