1 Product identity
Ingredient risk
6 ingredients to use with caution
Bio-Trophic Plus
BrandBiotics Research Corporation→Other Combinations Tablet or Pill 42 ingredients 6 caution DSLD #22066Net contents: 90 Tablet(s)
Target: Adults and Children 4 years and above
DSLD entry: 2013-06-25
2 Ingredients (42)
IngredientGroupSafety
Proprietary BlendProprietary Blend (Combination)—
RubidiumRubidium—
Gamma OryzanolGamma oryzanol—
Neonatal HeartHeart—
Neonatal KidneyKidney—
Neonatal LiverLiver—
Neonatal SpleenSpleen—
Buckwheat CultureBuckwheat —
FRAC(R)Ferulic Acid—
Citrus BioflavonoidsFlavonoid (mixture)—
Organic Beet ConcentrateBeet—
Superoxide DismutaseSuperoxide Dismutase—
CatalaseCatalase—
LithiumLithium—
Stearic AcidStearic Acid—
modified Cellulose GumCellulose—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
3 Safety cross-reference
Vitamin A — Limited Evidence
⚠ Teratogenic at high doses
⚠ Hepatotoxic with chronic excess
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Thiamin — Use with Caution
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Biotin — Generally Safe
⚠ Interferes with troponin and thyroid lab assays
Pantothenic Acid — Generally Safe
⚠ Diarrhea at very high doses
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Selenium — Conditionally Safe
⚠ Selenosis >400 mcg
⚠ Diabetes risk at high doses
Manganese — Conditionally Safe
⚠ Neurotoxicity with chronic excess
Chromium — Conditionally Safe
⚠ Hypoglycemia with diabetes meds
⚠ Rare renal/hepatic toxicity
Molybdenum — Generally Safe
⚠ Very low toxicity
Quercetin — Conditionally Safe
⚠ Inhibits CYP3A4
⚠ Affects cyclosporine levels
Vanadium — Limited Evidence
⚠ GI toxicity: nausea, vomiting, diarrhea
⚠ Green tongue
Green Tea Extract — Limited Evidence
⚠ HEPATOTOXICITY >800 mg EGCG
⚠ Iron absorption inhibition
GLA — Limited Evidence
⚠ May lower seizure threshold
⚠ Borage oil: hepatotoxic unless PA-free
Potassium — Limited Evidence
⚠ Hyperkalemia risk
⚠ Dangerous with ACE inhibitors
Silicon — Generally Safe
⚠ Very low toxicity
4 Label claims
• All Other
5 Data source
DSLD ID22066
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2013-06-25
6 More from Biotics Research Corporation
View Biotics Research Corporation Safety Scorecard → 240 products
5-HTP7-Keto-ZymeA.D.P.Acetyl-L-CarnitineADB5-PlusADHS7 Cite this page
Vancouver
Pkhakadze G. Bio-Trophic Plus — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jul 28]. Available from: https://supplement.ge/products/bio-trophic-plus-22066/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG