✓ No active regulatory warningsFDA MedWatch, EMA EudraVigilance, WHO VigiBase, WADA Prohibited List · 2026-05-29
Updated: 2026-05-29 · v2.0 · Prof. G. Pkhakadze, MD, MPH, PhDCiteEditorial
📰Read the full Ceramides evidence review on GMJ News →Complete clinical article, references and updates on news.gmj.ge. This page is the structured safety summary.
1
Safe
Ceramides
Phytoceramides (rice/wheat-derived)
Generally SafeLimitedOther
RDA
Typical 350 mg
Target
N/A
Upper limit
No UL
Products
1
Dosage by population group — reference
🔗 Best with: Hyaluronic Acid, Collagen Peptides, Vitamin C✅ USP Verified, NSF Contents Certified, ConsumerLab Approved
⚠ Topical ceramides have more evidence than oral [2]
⚠ Very small trial base (Japanese) [1]
ℹ️ Not obtained from food. Not applicable — this is not obtained from food in meaningful amounts; supplementation is the practical route.
🔬 Lab interpreter
ℹ️ No validated blood test. There is no established laboratory test to assess status or guide dosing for this ingredient. Clinical response and symptoms are the practical guide.
⚕ For professionals — confirm ranges against your local laboratory.
Clinical verdict
Oral ceramides: small Japanese trials positive for skin hydration at very low doses (0.6–1.8 mg). Topical ceramides (CeraVe) have stronger evidence. Both are valid but topical is better-supported [1] [2].
1 How much do I need?
👤 Adults: Specific dosage data under clinical review
👴 Elderly: Specific dosage data under clinical review
🤰 Pregnancy: See guidance
Likely safe (food-derived lipid) [1].
👦 Pediatric: See guidance
No data [1].
🏃 Athletes: Standard dose
⚖️ Obesity: Standard dose
Fat-soluble compounds may require dose adjustment in obesity.
🩺 Renal: Consult specialist
Dose adjustment may be needed in renal impairment.
🌱 Vegan: Standard dose

How to take

🍽 Timing: Any [1].
💊 With food: With fat [1].
🚫 Avoid: Wheat allergy (if wheat-derived) [1].
2 Which form?
FormBioavailabilityVeganCost
['Phytoceramide capsules', 'common', '0.6–1.8 mg/day [1].']StandardCheck label
3 Common questions
Oral vs topical ceramides? ▼
Topical (CeraVe, etc.) has stronger evidence for skin barrier repair. Oral has small positive Japanese trials for hydration. Both work through different routes [1] [2].
4 Clinical evidence

Strong

Ceramides are skin barrier lipids: established dermatology [1]. HIGH

Moderate

Oral: small Japanese RCTs positive for skin hydration [1]. Topical: CeraVe-type products are evidence-based for barrier repair [2]. MODERATE

Insufficient

Anti-aging clinical outcomes [1]. Eczema (oral) [1]. LOW
5 Safety, toxicity & adverse events

Relative

⚠ Wheat-derived products — caution in celiac disease/wheat allergy
⚠ Pregnancy and lactation — limited oral data
6 Interactions

Supplement synergies

HA + Collagen + Vitamin C · Standard doses
Comprehensive skin support [1].
7 Regulatory
United States: GRAS [1].
8 US supplement products
1
on-market products containing Ceramides (NIH DSLD)

Brands carrying Ceramides (1)

Click a brand to see its Ceramides products.
Or browse all 1 products in one list →
Ceramides vs Hyaluronic AcidCeramides vs Collagen Peptides
9 Cite this page
Vancouver: Pkhakadze G. Ceramides — safety profile [Internet]. Tbilisi: PHIG; 2026 [cited 2026 Aug 15]. Available from: https://supplement.ge/ingredients/ceramides/
APA 7th: Pkhakadze, G. (2026). Ceramides — Safety profile. Public Health Institute of Georgia. https://supplement.ge/ingredients/ceramides/
📋 Editorial information
Author: Prof. G. Pkhakadze, MD, MPH, PhD
Affiliation: David Tvildiani Medical University (DTMU)
First published: January 2026
Last reviewed: 2026-05-29
Next review: February 2027
References: 2 cited sources
COI: SupplementIndex receives no funding from supplement manufacturers. All content independently authored by PHIG.
Process: Systematic literature review
📄 License & reuse
Published under Creative Commons Attribution 4.0 International (CC BY 4.0). You may share and adapt for any purpose with attribution.
Pkhakadze G. "Ceramides — Safety Profile." SupplementIndex, PHIG, 2026. https://supplement.ge/ingredients/ceramides/ CC BY 4.0.
GP
Prof. G. Pkhakadze, MD, MPH, PhD
Professor of Public Health · Head of Department, DTMU
Editor-in-Chief, Georgian Medical Journal (ISSN 3088-4322)
Chair, Public Health Institute of Georgia · UEMS Public Health Section
Educational and public health purposes. CC BY 4.0. Consult your healthcare provider before starting any supplement. Corrections: info@accreditation.ge. Publisher: PHIG