1 Product identity
Ingredient risk
Contains restricted ingredients
C4 Extreme Watermelon
BrandCellucor→Other Combinations Powder 28 ingredients 1 banned 3 caution DSLD #12409Net contents: 60 Serving(s)
Target: Adults and Children 4 years and above
DSLD entry: 2012-10-01
2 Ingredients (28)
IngredientGroupSafety
CaloriesCalories—
Total CarbohydratesCarbohydrate—
Arginine AKGArginine Alpha Ketoglutarate—
Explosive Energy BlendBlend (Combination)—
Mucuna pruriensCowhage—
Artificial FlavorsFlavor—
Citric AcidCitric Acid—
Malic AcidMalic Acid—
FD&C Red Lake #40Color—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ Contains an ingredient banned in ≥1 country
Bitter Orange — but minimal α-1/α-2 activity (distinguishing it from the banned ephedrine) [1]. Despite widespread use in fat-burners and pre-workouts, c
⚠️ Use with caution — restricted in some markets
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Caffeine (Anhydrous) 🇬🇧 🇪🇺 🇦🇺 — High caffeine warnings mandatory on products >150 mg/L.
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
3 Safety cross-reference
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Beta-Alanine — Generally Safe
⚠ Tingling (paraesthesia) — harmless
Creatine — Generally Safe
⚠ Water retention
⚠ Weight gain
L-Tyrosine — Limited Evidence
⚠ May worsen hyperthyroidism
⚠ Migraine trigger in some
Caffeine (Anhydrous) — Use with Caution
Bitter Orange — Banned in ≥1 country
⚠ Cardiovascular events when combined with caffeine
⚠ Hypertension, tachycardia
Vitamin B6 — Use with Caution
Silicon — Generally Safe
⚠ Very low toxicity
Sucralose — Conditionally Safe
⚠ May affect gut microbiome
⚠ Heating may produce chlorinated compounds
Potassium — Limited Evidence
⚠ Hyperkalemia risk
⚠ Dangerous with ACE inhibitors
4 Label claims
• All Other
• Structure/Function
5 Data source
DSLD ID12409
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2012-10-01
6 More from Cellucor
View Cellucor Safety Scorecard → 76 products
Alpha Amino Fruit PunchAlpha Amino Fruit PunchAlpha Amino Fruit PunchAlpha Amino Fruit PunchAlpha Amino Icy Blue RazzAlpha Amino Icy Blue Razz7 Cite this page
Vancouver
Pkhakadze G. C4 Extreme Watermelon — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jul 27]. Available from: https://supplement.ge/products/c4-extreme-watermelon-12409/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG