1 Product identity
Ingredient risk
4 ingredients to use with caution

B-Supreme

BrandDesigns for Health→Other Combinations Capsule 17 ingredients 4 caution DSLD #22273
Net contents: 60 Vegetarian Capsule(s)
Target: Adults and Children 4 years and above
DSLD entry: 2013-08-23
2 Ingredients (17)
IngredientGroupSafety
ThiamineThiaminUse with Caution
RiboflavinRiboflavinGenerally Safe
Riboflavin HydrochlorideRiboflavinGenerally Safe
Riboflavin 5-PhosphateRiboflavinGenerally Safe
NiacinNiacinConditionally Safe
Vitamin B6Vitamin B6Use with Caution
Pyridoxine HydrochlorideVitamin B6Use with Caution
Pyridoxal 5-PhosphateVitamin B6Use with Caution
NatureFolate BlendProprietary Blend—
Vitamin B12Vitamin B12Use with Caution
BiotinBiotinGenerally Safe
Pantothenic AcidPantothenic Acid (Vitamin B5)—
CholineCholineGenerally Safe
TrimethylglycineBetaine—
Microcrystalline CelluloseCellulose—
Silicon DioxideSiliconGenerally Safe
Vegetable StearateMagnesium stearateUse with Caution
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⚠️ Use with caution — restricted in some markets
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
3 Safety cross-reference
Thiamin — Use with Caution
⚠ Very low toxicity
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Limited Evidence
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Biotin — Generally Safe
⚠ Interferes with troponin and thyroid lab assays
Pantothenic Acid — Limited Evidence
⚠ Diarrhea at very high doses
Choline — Generally Safe
⚠ Fishy odor at high doses
Glycine — Limited Evidence
⚠ Well tolerated
Silicon — Generally Safe
⚠ Very low toxicity
Magnesium — Use with Caution
4 Label claims
• All Other
5 Data source
DSLD ID22273
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2013-08-23
6 More from Designs for Health
View Designs for Health Safety Scorecard → 261 products
5-HTP Supreme5-HTP Synergy7-KetoAcetyl L-CarnitineAcnutrolAdrenal Complex
7 Cite this page
Vancouver
Pkhakadze G. B-Supreme — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Jun 25]. Available from: https://supplement.ge/products/b-supreme-22273/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG