Agaricus Blazei — Safety Profile

Pkhakadze, Giorgi

✓ No active regulatory warningsFDA MedWatch, EMA EudraVigilance, WHO VigiBase, WADA Prohibited List · 2026-05-29

Updated: 2026-05-29 · v2.0 · Prof. G. Pkhakadze, MD, MPH, PhDCite Editorial

📰Read the full Agaricus Blazei evidence review on GMJ News →Complete clinical article, references and updates on news.gmj.ge. This page is the structured safety summary.

2

Conditional

Agaricus Blazei

Agaricus blazei Murill (ABM)

Conditionally SafeLimitedMushrooms

RDA

Typical 500–1,500 mg

Target

N/A

Upper limit

No UL

Products

5

Dosage by population group — reference

🔗 Best with: Reishi, Turkey Tail, Maitake✅ USP Verified, ConsumerLab Approved, USDA Organic

⚠ Cadmium bioaccumulation — verify heavy metal testing [2]

⚠ Weakest evidence base among popular medicinal mushrooms [2]

⚠ Transplant patient — immunostimulation [1]

ℹ️ Not obtained from food. Not applicable — this is not obtained from food in meaningful amounts; supplementation is the practical route.

🔬 Lab interpreter

ℹ️ No validated blood test. There is no established laboratory test to assess status or guide dosing for this ingredient. Clinical response and symptoms are the practical guide.

⚕ For professionals — confirm ranges against your local laboratory.

Clinical verdict

ABM has beta-glucan immunomodulation like other medicinal mushrooms but with the WEAKEST clinical evidence base. Cadmium bioaccumulation is a specific safety concern — verify heavy metal testing. Turkey Tail and Reishi are better-evidenced choices. Popular in Japan/Brazil [1] [2].

1 How much do I need?

👤 Adults: Specific dosage data under clinical review

👴 Elderly: Specific dosage data under clinical review

🤰 Pregnancy: See guidance

No data. Cadmium concern [2].

👦 Pediatric: See guidance

No data. Cadmium concern [2].

🏃 Athletes: Standard dose

⚖️ Obesity: Standard dose

Fat-soluble compounds may require dose adjustment in obesity.

🩺 Renal: Consult specialist

Dose adjustment may be needed in renal impairment.

🌱 Vegan: Standard dose

How to take

🍽 Timing: Any time [1].

💊 With food: With or without food [1].

🚫 Avoid: Unverified products (cadmium) [2]. Immunosuppressants [1].

2 Which form?

Form	Bioavailability	Vegan	Cost
['ABM extract (beta-glucan enriched)', 'preferred', 'Standardized. Verify heavy metal testing [2].']	Standard	Check label
['Dried ABM mushroom', 'common', 'Traditional. Variable quality [1].']	Standard	Check label

3 Common questions

Is ABM safe? ▼

Generally yes, BUT cadmium bioaccumulation is a real concern. ABM grown on contaminated substrate can contain high cadmium levels. Always use products with third-party heavy metal testing [2].

ABM vs Turkey Tail vs Reishi? ▼

Turkey Tail (PSK) has the most cancer clinical evidence. Reishi has the broadest traditional use. ABM has the weakest evidence base among the popular medicinal mushrooms [1] [2].

4 Clinical evidence

Strong

Beta-glucan immunomodulation: Dectin-1 activation (same as other mushroom beta-glucans) [1]. HIGH

Moderate

Immune markers: improved NK cell activity in small Japanese studies [2]. Cancer adjunct: some quality of life improvement data (small trials) [2]. Hepatoprotective: some animal data [1]. MODERATE

Insufficient

Cancer treatment [2]. Diabetes [1]. Cardiovascular [1]. Allergies [1]. All major claims lack adequate human trial data [2]. LOW

5 Safety, toxicity & adverse events

Absolute contraindications

✕ Mushroom hypersensitivity

Relative

⚠ Autoimmune disease — immunostimulant

⚠ Liver disease — rare hepatotoxicity reports

⚠ Pregnancy and lactation — limited data

🚩 Red flags

● Product without heavy metal testing — cadmium risk [2]

● Transplant patient [1]

6 Interactions

Drug interactions

Immunosuppressants Moderate

Mechanism: Beta-glucan immunostimulation. [1]

Effect: May oppose immunosuppression. [1]

Action: Avoid [1].

Supplement synergies

Other medicinal mushrooms (Reishi, Turkey Tail) · Standard doses
Different beta-glucan profiles [1].

7 Regulatory

Japan: Popular supplement and functional food [1].

Brazil: Traditional medicine (Cogumelo do Sol) [1].

United States: Dietary supplement [1].

8 US supplement products

5

on-market products containing Agaricus Blazei (NIH DSLD)

Brands carrying Agaricus Blazei (4)

Click a brand to see its Agaricus Blazei products.

Or browse all 5 products in one list →

9 Frequently paired with

Cordyceps 5 shared Zinc 2 shared

Agaricus Blazei vs Reishi Agaricus Blazei vs Turkey Tail

10 Cite this page

Vancouver: Pkhakadze G. Agaricus Blazei — safety profile [Internet]. Tbilisi: PHIG; 2026 [cited 2026 Oct 18]. Available from: https://supplement.ge/ingredients/agaricus-blazei/

APA 7th: Pkhakadze, G. (2026). Agaricus Blazei — Safety profile. Public Health Institute of Georgia. https://supplement.ge/ingredients/agaricus-blazei/

📋 Editorial information

Author: Prof. G. Pkhakadze, MD, MPH, PhD

Institution: Public Health Institute of Georgia (PHIG)

Affiliation: David Tvildiani Medical University (DTMU)

First published: January 2026

Last reviewed: 2026-05-29

Next review: April 2027

References: 2 cited sources

COI: SupplementIndex receives no funding from supplement manufacturers. All content independently authored by PHIG.

Process: Systematic literature review

📄 License & reuse

Published under Creative Commons Attribution 4.0 International (CC BY 4.0). You may share and adapt for any purpose with attribution.

Pkhakadze G. "Agaricus Blazei — Safety Profile." SupplementIndex, PHIG, 2026. https://supplement.ge/ingredients/agaricus-blazei/ CC BY 4.0.

GP

Prof. G. Pkhakadze, MD, MPH, PhD

Professor of Public Health · Head of Department, DTMU

Editor-in-Chief, Georgian Medical Journal (ISSN 3088-4322)

Chair, Public Health Institute of Georgia · UEMS Public Health Section

🏛 PHIG 📰 GMJ 🆔 ORCID

Educational and public health purposes. CC BY 4.0. Consult your healthcare provider before starting any supplement. Corrections: info@accreditation.ge. Publisher: PHIG