✓
No active regulatory warnings
Sources: FDA MedWatch, EMA EudraVigilance, WHO VigiBase, WADA Prohibited List · 2026-05-29
Updated: 2026-05-29 · v2.0 · Prof. G. Pkhakadze, MD, MPH, PhD📎 Cite 📄 PDF
1 Identity

Testosterone Boosters

Various: Tribulus + Fenugreek + D-AA + Zinc blends
Limited EvidenceEvidence: LimitedOther
Testosterone boosters are a supplement CATEGORY (not a single ingredient) typically combining tribulus, fenugreek, D-aspartic acid, ashwagandha, zinc, and/or DHEA [1]. A systematic review found the vast majority of marketed testosterone boosters have NO evidence of increasing testosterone. Of 109 products analyzed, only 24.8% of ingredients had ANY evidence supporting T elevation — and most of that evidence was weak or in specific populations (e.g., ashwagandha in infertile men, not healthy young athletes) [2]. The category is dominated by marketing, not science [1].
3
Testosterone Boosters
Various: Tribulus + Fenugreek + D-AA + Zinc blends
Limited EvidenceEvidence: LimitedOther
Clinical verdict: Testosterone boosters as a supplement CATEGORY are overwhelmingly unsupported: only 24.8% of ingredients in 109 products had ANY T-elevation evidence. The few ingredients with genuine data: ashwagandha (in infertile/stressed men), zinc (only if deficient), vitamin D (only if deficient). Tribulus: conclusively negative. D-aspartic acid: transiently raises T for ~2 weeks then returns to baseline. DHEA: converts to estrogen as readily as testosterone in men. The category is marketing-driven [1] [2].
RDA
Varies by formula
Target range
N/A
Upper limit
N/A
Evidence
Limited
Population dosing — click to filter
✅ USP Verified, NSF Contents Certified, ConsumerLab Approved
2 Risk self-assessment
See overview [1].
Select factors above to see your risk level
Clinical pearl for practitioners
SupplementIndex
Testosterone Boosters
Various: Tribulus + Fenugreek + D-AA + Zinc blends · Limited Evidence · Evidence: Limited
RDA
Varies by formula
Upper limit
N/A
Evidence
Limited
Clinical bottom line
Testosterone boosters as a supplement CATEGORY are overwhelmingly unsupported: only 24.8% of ingredients in 109 products had ANY T-elevation evidence. The few ingredients with genuine data: ashwagandha (in infertile/stressed men), zinc (only if deficient), vitamin D (only if deficient). Tribulus: conclusively negative. D-aspartic acid: transiently raises T for ~2 weeks then returns to baseline. DHEA: converts to estrogen as readily as testosterone in men. The category is marketing-driven [1] [2].
Do not miss
⚠ See overview for critical safety points [1]
Pregnancy
NOT APPLICABLE — testosterone boosters are used by men [1].
4 Lab interpreter

See overview

<12 Deficient
12–20 Insufficient
20–50 Optimal
50–100 Excess
>150 Toxic
Your level:
Enter a value above
⚕ For healthcare professionals. Does not replace clinical judgment.
5 Quick facts
CategoryOther
Safety levelLimited Evidence
EvidenceLimited
RDAVaries by formula
Upper limit (UL)N/A
Scientific nameVarious: Tribulus + Fenugreek + D-AA + Zinc blends
See overview[1]
6 Dosage by population

Adults Moderate

See product label

Elderly Moderate

See product label
Consider reduced renal/hepatic clearance. Start at lower end of range.

Pregnancy Moderate

See guidance
NOT APPLICABLE — testosterone boosters are used by men [1].

Pediatric Moderate

See guidance
Not recommended without specialist guidance [1].

Athletes Limited

Standard dose

Obesity Limited

Standard dose
Fat-soluble compounds may require dose adjustment in obesity.

Renal Limited

Consult specialist
Dose adjustment may be needed in renal impairment.

Vegan Moderate

Standard dose
See overview for dosing guidance [1].
7 Form comparison
FormBioavailabilityVeganCost/day
['Various commercial forms', 'standard', 'See product labels [1].']StandardCheck label
8 Clinical evidence

Strong evidence

See overview [1]. HIGH

Moderate evidence

See overview [1]. MODERATE

Insufficient evidence

See overview [1]. LOW
9 Safety

🚩 Red flags — when to stop and refer

● See overview for safety alerts [1]

Pregnancy

NOT APPLICABLE — testosterone boosters are used by men [1].

Pediatric

Not recommended without specialist guidance [1].
10 Toxicity and overdose

11 Drug interactions
Hormone-sensitive conditions Major
Mechanism: Any actual T elevation could worsen prostate cancer, sleep apnea, erythrocytosis [1].
Effect: See overview [1].
Action: See overview [1].
12 Supplement interactions
13 Laboratory monitoring
See overview Primary
Target: N/A · N/A
See overview [1].
14 Deficiency and prevalence
0%
[1]

Risk factors

• See overview [1].
15 Frequently asked questions
Key clinical point ▼
Testosterone boosters as a supplement CATEGORY are overwhelmingly unsupported: only 24.8% of ingredients in 109 products had ANY T-elevation evidence. The few ingredients with genuine data: ashwagandha (in infertile/stressed men), zinc (only if deficient), vitamin D (only if deficient). Tribulus: conclusively negative. D-aspartic acid: transiently raises T for ~2 weeks then returns to baseline. DHEA: converts to estrogen as readily as testosterone in men. The category is marketing-driven [1] [2].
16 Regulatory status
United States (FDA): Dietary supplement / restricted [1].
17 References
[1]Clemesha CG, et al. 'Testosterone boosters' supplements: a comprehensive review of the literature. Curr Urol Rep. 2020;21(4):19. doi:10.1007/s11934-020-0968-1 REVIEW
[2]Pokrywka A, et al. Insights into supplements with Tribulus terrestris used by athletes. J Hum Kinet. 2014;41:99-105. doi:10.2478/hukin-2014-0037 REVIEW
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19 Cite this page
Vancouver
Pkhakadze G. Testosterone Boosters — safety profile [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 May 30]. Available from: https://supplement.ge/ingredients/testosterone-boosters/
APA 7th
Pkhakadze, G. (2026). Testosterone Boosters — Safety profile. Public Health Institute of Georgia. https://supplement.ge/ingredients/testosterone-boosters/
CC BY 4.0
🛡 SupplementIndex receives no funding from supplement manufacturers. All content independently authored by PHIG.
GP
Reviewed by Prof. G. Pkhakadze, MD, MPH, PhD
Editor-in-Chief, Georgian Medical Journal · Chair, PHIG
Last reviewed: May 2026 · Next: November 2026
This entry is provided for educational and public health purposes under CC BY 4.0. Consult your healthcare provider before starting any supplement. For corrections: info@accreditation.ge.
Publisher: PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD