CAU
Greater Celandine
Chelidonium majus standardised
Use with Caution
V1 Verified
Liver Herbs
PubMed Studies
1
About
Contains isoquinoline alkaloids including chelidonine with choleretic and antispasmodic effects. Liver function: hepatotoxicity documented.
How it works (mechanism of action)
Provides hepatoprotective effects via antioxidant enzyme induction (GPx, SOD), NF-kB suppression reducing hepatocyte apoptosis, and cytochrome P450 modulation. Choleretic action stimulates bile flow and composition benefiting lipid digestion and hepatic detoxification.
⚖️ Regulatory Status
⚠️
EU — Restricted
EMA HMPC safety review (2011) — hepatotoxicity risk. Member states advised to restrict. Germany BfArM risk communication issued.
⚠️
US — Restricted
FDA MedWatch alerts (2012) — hepatotoxicity cases reported.
👥 Safety by Population
🚫 Contraindications & Warnings
EMA/HMPC warning on hepatotoxicity. Not recommended without medical supervision.
🏷️ Other Names
Chelidonium majus standardised