✓
No active regulatory warnings
Sources: FDA MedWatch, EMA EudraVigilance, WHO VigiBase, WADA Prohibited List · 2026-05-29
Updated: 2026-05-29 · v2.0 · Prof. G. Pkhakadze, MD, MPH, PhD📎 Cite 📄 PDF
1 Identity

Belladonna

Atropa belladonna (atropine/scopolamine)
BannedEvidence: StrongRestricted
Belladonna (Atropa belladonna, deadly nightshade) contains tropane alkaloids (atropine, scopolamine, hyoscyamine) — anticholinergic agents that cause 'anticholinergic toxidrome': hot as a hare, blind as a bat, dry as a bone, red as a beet, mad as a hatter [1]. Homeopathic belladonna products have caused infant deaths (FDA warned about Hyland's teething tablets). At pharmacological doses, tropane alkaloids are PRESCRIPTION DRUGS (atropine). In supplements, belladonna appears in homeopathic preparations and some traditional formulas [1].
5
Belladonna
Atropa belladonna (atropine/scopolamine)
BannedEvidence: StrongRestricted
Clinical verdict: Belladonna is DEADLY NIGHTSHADE containing atropine/scopolamine — prescription drugs at therapeutic doses, LETHAL at higher doses. Anticholinergic toxidrome. Hyland's teething tablets (homeopathic belladonna) caused INFANT DEATHS — FDA warned. Even 'homeopathic' dilutions have been found to contain pharmacologically active amounts due to manufacturing inconsistency [1].
RDA
TOXIC — medicinal doses Rx only
Target range
N/A
Upper limit
No safe supplement dose
Evidence
Strong
Population dosing — click to filter
2 Risk self-assessment
DANGEROUS [1].
Select factors above to see your risk level
Clinical pearl for practitioners
SupplementIndex
Belladonna
Atropa belladonna (atropine/scopolamine) · Banned · Evidence: Strong
RDA
TOXIC — medicinal doses Rx only
Upper limit
No safe supplement dose
Evidence
Strong
Clinical bottom line
Belladonna is DEADLY NIGHTSHADE containing atropine/scopolamine — prescription drugs at therapeutic doses, LETHAL at higher doses. Anticholinergic toxidrome. Hyland's teething tablets (homeopathic belladonna) caused INFANT DEATHS — FDA warned. Even 'homeopathic' dilutions have been found to contain pharmacologically active amounts due to manufacturing inconsistency [1].
Do not miss
⚠ DANGEROUS — see overview [1]
Pregnancy
ABSOLUTELY CONTRAINDICATED [1].
4 Lab interpreter

See overview

<12 Deficient
12–20 Insufficient
20–50 Optimal
50–100 Excess
>150 Toxic
Your level:
Enter a value above
⚕ For healthcare professionals. Does not replace clinical judgment.
5 Quick facts
CategoryRestricted
Safety levelBanned
EvidenceStrong
RDATOXIC — medicinal doses Rx only
Upper limit (UL)No safe supplement dose
Scientific nameAtropa belladonna (atropine/scopolamine)
DANGEROUS/RESTRICTED — see overview[1]
6 Dosage by population

Adults Moderate

See product label

Elderly Moderate

See product label
Consider reduced renal/hepatic clearance. Start at lower end of range.

Pregnancy Moderate

See guidance
ABSOLUTELY CONTRAINDICATED [1].

Pediatric Moderate

See guidance
ABSOLUTELY NOT [1].

Athletes Limited

Standard dose

Obesity Limited

Standard dose
Fat-soluble compounds may require dose adjustment in obesity.

Renal Limited

Consult specialist
Dose adjustment may be needed in renal impairment.

Vegan Moderate

Standard dose
DANGEROUS — NOT for supplementation. See overview [1].
7 Form comparison
FormBioavailabilityVeganCost/day
['See overview', 'restricted/banned', 'See overview [1].']StandardCheck label
8 Clinical evidence

Strong evidence

See overview [1]. HIGH

Moderate evidence

See overview [1]. MODERATE

Insufficient evidence

See overview [1]. LOW
9 Safety

🚩 Red flags — when to stop and refer

● DANGEROUS — see overview [1]

Pregnancy

ABSOLUTELY CONTRAINDICATED [1].

Pediatric

ABSOLUTELY NOT [1].
10 Toxicity and overdose

11 Drug interactions
See overview Lethal/major
Mechanism: See overview [1].
Effect: See overview [1].
Action: DO NOT USE [1].
12 Supplement interactions
13 Laboratory monitoring
See overview Primary
Target: N/A · N/A
See overview [1].
14 Deficiency and prevalence
0%
[1]

Risk factors

• DANGEROUS [1].
15 Frequently asked questions
DANGER ▼
Belladonna is DEADLY NIGHTSHADE containing atropine/scopolamine — prescription drugs at therapeutic doses, LETHAL at higher doses. Anticholinergic toxidrome. Hyland's teething tablets (homeopathic belladonna) caused INFANT DEATHS — FDA warned. Even 'homeopathic' dilutions have been found to contain pharmacologically active amounts due to manufacturing inconsistency [1].
16 Regulatory status
BANNED/RESTRICTED — see overview: [1].
17 References
[1]See overview. REVIEW
18 US supplement products
1
on-market US dietary supplements contain Belladonna
Source: NIH Dietary Supplement Label Database (DSLD). Cross-referenced with SupplementIndex safety profiles.

Top brands

T-Relief1 products

Product forms

Tablet or Pill (1)

Sample products

CBD+13 T-ReliefTablet or Pill
View all 1 products containing Belladonna →
19 Related articles
📰 Article placeholder — auto-populated via news.gmj.ge
📰 Article placeholder — auto-populated via news.gmj.ge
📰 Article placeholder — auto-populated via news.gmj.ge
📰 Article placeholder — auto-populated via news.gmj.ge
Auto-updated from GMJ Newsroom. Articles tagged "Belladonna" appear here.
20 Cite this page
Vancouver
Pkhakadze G. Belladonna — safety profile [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 May 30]. Available from: https://supplement.ge/ingredients/belladonna/
APA 7th
Pkhakadze, G. (2026). Belladonna — Safety profile. Public Health Institute of Georgia. https://supplement.ge/ingredients/belladonna/
CC BY 4.0
🛡 SupplementIndex receives no funding from supplement manufacturers. All content independently authored by PHIG.
GP
Reviewed by Prof. G. Pkhakadze, MD, MPH, PhD
Editor-in-Chief, Georgian Medical Journal · Chair, PHIG
Last reviewed: May 2026 · Next: November 2026
This entry is provided for educational and public health purposes under CC BY 4.0. Consult your healthcare provider before starting any supplement. For corrections: info@accreditation.ge.
Publisher: PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD