SAFE
Ziziphus Jujube
Ziziphus jujuba (Da Zao/Jujube)
Likely Safe
V1 Verified
Adaptogens
PubMed Studies
8
About
Jujube fruit with GABA-modulating flavonoids. Used for anxiety, insomnia, and digestive support.
How it works (mechanism of action)
Modulates hypothalamic-pituitary-adrenal (HPA) axis and sympathoadrenal system to normalise physiological responses to stress. Activates heat shock proteins and stress-response pathways providing non-specific resistance to physical, chemical, and biological stressors.
📊 Effectiveness
Sleep quality
Evidence Grade B · 10 studies · n=820
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
👥 Safety by Population
🚫 Contraindications & Warnings
CNS depressant interaction. Blood sugar effects. Generally very safe.
🏷️ Other Names
Ziziphus jujuba (Da Zao/Jujube)