SAFE
Sodium metabisulfite
Sodium metabisulfite (E223)
Possibly Safe
V2 Verified
Excipients & Additives
PubMed Studies
16
PubChem CID
About
Sulphite preservative and antioxidant. E223. Releases sulphur dioxide (SO2) which is the active antimicrobial form. All sulphite-releasing compounds must be declared on labels if >10mg/kg SO2 equivalent.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
👥 Safety by Population
🚫 Contraindications & Warnings
ASTHMA: Sulphites are among the most important dietary triggers for asthma — can precipitate severe bronchospasm. Mandatory labelling in EU and USA if >10mg/kg SO2 equivalent. CONTRAINDICATED in sulphite-sensitive individuals. Destroys thiamine (B1). WHO ADI: 0.7mg/kg/day SO2 equivalent.
🏷️ Other Names
Sodium metabisulfite (E223)