SAFE
Mangosteen Extract
Garcinia mangostana (alpha and gamma mangostin)
Likely Safe
V1 Verified
Antioxidants
PubMed Studies
2
About
Xanthones with anti-inflammatory, antioxidant, and antimicrobial properties.
How it works (mechanism of action)
Directly quenches reactive oxygen species (ROS) and reactive nitrogen species (RNS) preventing oxidative damage to DNA, proteins, and lipids. Activates endogenous antioxidant defence pathways (Nrf2/HO-1) and regenerates or spares other antioxidants through redox cycling.
📊 Effectiveness
Antioxidant
Evidence Grade C · 6 studies · n=380
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
👥 Safety by Population
🚫 Contraindications & Warnings
GI effects at high doses. Anticoagulant interaction. Laxative effect.
🇪🇺 EU Health Claims Status
Art.13(1)
✓ AuthorisedNon-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food is not a beneficial physiological effect as required by the Regulation.
Regulation EU 1924/2006 · ART13 1
Art.13(1)
✓ AuthorisedNon-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food has not been substantiated.
Regulation EU 1924/2006 · ART13 1
Art.13(1)
✓ AuthorisedNon-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food is not sufficiently defined to be able to be assessed and the claim could not therefore be substantiated.
Regulation EU 1924/2006 · ART13 1
Art.13(1)
✓ AuthorisedNon-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food has not been substantiated.
Regulation EU 1924/2006 · ART13 1
🏷️ Other Names
Garcinia mangostana (alpha and gamma mangostin)