SAFE

Grapefruit oil

Citrus paradisi peel essential oil
Possibly Safe V2 Verified Excipients & Additives
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PubMed Studies
3
About

Cold-pressed essential oil from grapefruit peel containing limonene and furanocoumarin compounds. Furanocoumarin (bergapten) content a concern. IMPORTANT: grapefruit interactions with CYP3A4 apply primarily to grapefruit juice (furanocoumarins in juice membrane).

How it works (mechanism of action)

Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralPossibly safeNot established
PregnancyPossibly safeNot established
ElderlyPossibly safeNot established
🚫 Contraindications & Warnings

CYP3A4 INTERACTION: Bergapten and other furanocoumarins in grapefruit inhibit CYP3A4 — significant drug interaction potential with statins, calcium channel blockers, immunosuppressants, and many other medications. Cold-pressed peel oil contains furanocoumarins (unlike steam-distilled oil). Photosensitisation with topical use. Furanocoumarin content must be assessed.

🇪🇺 EU Health Claims Status
Art.13(1)
✓ Authorised
Non-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food has not been substantiated.
Regulation EU 1924/2006 · ART13 1
Art.13(1)
✓ Authorised
Non-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food has not been substantiated.
Regulation EU 1924/2006 · ART13 1
Art.13(1)
✓ Authorised
Non-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food is not a beneficial physiological effect as required by the Regulation.
Regulation EU 1924/2006 · ART13 1
🏷️ Other Names
Citrus paradisi peel essential oil
Updated: 2026-04-11
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